Association between an HLA haplotype and low responsiveness to schistosomal worm antigen in man.
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TL;DR
It was suggested that the low responsiveness to schistosomal worm antigen was controlled by a single dominant immune suppression gene that was in strong linkage disequilibrium with HLA-Dw12.
Abstract
Immune responsiveness to schistosomal worm antigen was investigated in the individuals infected with Schistosoma japonicum by measuring the antigen-specific proliferative response of the peripheral T lymphocytes in vitro. Out of 57 infected individuals, 10 (17.5%) were low responders, whereas 47 (82.5%) were high responders to this antigen. The strong association between the HLA-Aw24-Bw52-Dw12 haplotype and the low responder group was demonstrated. Because the association of the low responder group was strongest with the HLA-D specificity, Dw12, and because the HLA-D region was assumed to be comparable to the I region of the murine H-2 complex, it was suggested that the low responsiveness to schistosomal worm antigen was controlled by a single dominant immune suppression gene that was in strong linkage disequilibrium with HLA-Dw12.