A kinetic hairpin transfer model for parvoviral DNA replication
Journal of Molecular BiologyPublished 1 July 1989
Katherine C. Chen, John J. Tyson, Muriel Lederman, Ernest R. Stout, Robert C. Bates
Citations27
SJR quartileQ1
SJR score2.21
SNIP1.13
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
A kinetic model, based on differential rates of hairpin transfer at 3' termini, is described and shown to account for all known parvoviral DNA distributions.
Abstract
The DNAs encapsidated by parvoviruses show distinctly different patterns with respect to the ratio of plus-to-minus strands and sequence heterogeneity at the ends. A kinetic model, based on differential rates of hairpin transfer at 3' termini, is described and shown to account for all known parvoviral DNA distributions.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
Advances in virus researchThe Autonomously Replicating Parvoviruses of Vertebrates
481 Citations1987Susan F. Cotmore, Peter Tattersall
This chapter reviews the current state of knowledge of autonomous parvovirus structure and replication and explores the strategies employed by these viruses—at the molecular and cellular levels—to parasitize their various hosts.
Journal of VirologyA recombinant plasmid from which an infectious adeno-associated virus genome can be excised in vitro and its use to study viral replication
444 Citations1987R. Jude Samulski, Long‐Sheng Chang +1 more
Viral DNA was replicated more efficiently within adenovirus-infected 293 cells if it was excised from the vector with PvuII before transfection and bypass of the excision step which must normally precede replication when a recombinant plasmid enters the nucleus.
Journal of VirologyNucleotide sequence and genome organization of human parvovirus B19 isolated from the serum of a child during aplastic crisis
435 Citations1986Rosemary O. Shade, Matthew C. Blundell +3 more
Analysis of the putative polypeptides confirms that B19 is only distantly related to the other parvoviruses but reveals that there is a small region in the gene probably encoding the major nonstructural protein of B19, which is closely conserved between all of theParvovirus genomes for which sequence information is currently available.
Journal of VirologyAdeno-associated virus general transduction vectors: analysis of proviral structures
342 Citations1988Sherry McLaughlin, Phil Collis +2 more
The results suggest that AAV sequences are amplified by DNA replication either before or after integration and that the mechanism of replication is different from the one used during AAV lytic infections.
IntervirologyCharacteristics and Taxonomy of <i>Parvoviridae</i>
307 Citations1985G. Siegl, Robert C. Bates +5 more
CellRescue of adeno-associated virus from recombinant plasmids: Gene correction within the terminal repeats of AAV
301 Citations1983R. Jude Samulski, Arun Srivastava +2 more
There is an efficient mechanism for correcting deletions within the AAV termini, and the viable type III deletion could be converted to a nonviable mutant by deleting all copies of an 11 bp sequence from its termini.
NaturePalindromic base sequences and replication of eukaryote chromosome ends
279 Citations1974Thomas Cavalier‐Smith
A new theory is proposed to explain the synthesis of the 5′ ends of linear DNA molecules, which suggests that chromosome ends consist of palindromic base sequences that can form self-complementary hairpin loops.
NatureRolling hairpin model for replication of parvovirus and linear chromosomal DNA
239 Citations1976Peter Tattersall, David C. Ward
A novel, quasicircular scheme is proposed for the replication of parvovirus DNA, in which daughter strands are initiated after the copying and rearrangement of a terminal palindromic sequence, a process termed ‘hairpin transfer’.
Journal of VirologyNucleotide sequence of the inverted terminal repetition in adeno-associated virus DNA
228 Citations1980Edward W. Lusby, K H Fife +1 more
A model for adeno-associated virus DNA replication is presented which agrees in detail with a general model for eucaryotic DNA replication originally proposed by Cavalier-Smith.
Journal of VirologyReplication of adeno-associated virus in synchronized cells without the addition of a helper virus
217 Citations1987Bracha Yakobson, Tamar Koch +1 more
The results demonstrate that, in contrast to previous notions, the AAV infectious process is not absolutely dependent upon the addition of a coinfecting helper virus.
Advances in virus researchAdeno-Associated Viruses: An Update
207 Citations1987Kenneth I. Berns, Roy A. Bohenzky
Adeno-associated virus does not have any structural relatedness to either of its helpers; on the other hand, the three viruses do represent all of the known vertebrate virus families with linear DNA genomes that replicate in cell nuclei.
VirologyVaccinia virus, herpes simplex virus, and carcinogens induce DNA amplification in a human cell line and support replication of a helpervirus dependent parvovirus
187 Citations1986Jörg R. Schlehofer, M. Ehrbar +1 more
It is shown that vaccinia virus induces SV40 DNA amplification also in the SV40-transformed Chinese hamster embryo cell line, CO631, and a poxvirus--vaccinia virus--similar to herpes group viruses induces DNA amplification.
ScienceCharacterization and Molecular Cloning of a Human Parvovirus Genome
178 Citations1984Susan F. Cotmore, Peter Tattersall
The genome of the small human virus serologically associated with erythrocyte aplasia and erythema infectiosum (fifth disease) is shown to be a linear, nonpermuted, single-stranded DNA molecule with self-priming hairpin termini, properties which are characteristic of the genomes of the family Parvoviridae.
Journal of VirologyReplication of adeno-associated virus in cells irradiated with UV light at 254 nm
139 Citations1989Bracha Yakobson, T A Hrynko +2 more
Irradiation of simian virus 40 (ori mutant)-transformed Chinese hamster embryo cells (OD4 line) with UV light induced a cellular capacity which supported a full cycle of helper-independent adeno-associated virus replication, indicating a requirement for de novo protein synthesis.
Journal of VirologyThe NS-1 polypeptide of minute virus of mice is covalently attached to the 5' termini of duplex replicative-form DNA and progeny single strands
123 Citations1988Susan F. Cotmore, Peter Tattersall
Preipitation of the replicating viral DNA with an antibody directed against a synthetic 16-amino-acid peptide containing the sequence at the extreme carboxy terminus of NS-1 can be quantitatively and specifically inhibited with the immunizing peptide in its unconjugated form, showing that the antibodies responsible for precipitating viral DNA are directed against the NS- 1 sequence itself and not against a trace contaminant.
Journal of VirologySequence analysis of the termini of virion and replicative forms of minute virus of mice DNA suggests a modified rolling hairpin model for autonomous parvovirus DNA replication
114 Citations1985Caroline R. Astell, M Chow +1 more
A modified rolling hairpin model for the replication of autonomous parvoviruses which is compatible with all available data is proposed.
CellStructure of the 3′ hairpin termini of four rodent parvovirus genomes: Nucleotide sequence homology at origins of DNA replication
105 Citations1979Caroline R. Astell, Michael J. Smith +2 more
The nucleotide sequences of the 3' termini of the DNA from four autonomous rodent parvoviruses have been determined and shows no evidence of internal sequence heterogeneity, a characteristic which is observed in the terminal nucleotide sequence of the helper-dependent, adeno-associated viruses.
Journal of VirologyDNA sequence of the 5' terminus containing the replication origin of parvovirus replicative form DNA
54 Citations1982S L Rhode, Belia Klaassen
This region contains the replication origin for parvovirus replicative form DNA replication and is an AT-rich region that is noncoding and contains a 55-base-pair tandem repeat.
Journal of VirologyInverted terminal repetition in adeno-associated virus DNA: independence of the orientation at either end of the genome
42 Citations1981Edward W. Lusby, Roy A. Bohenzky +1 more
The orientation of the terminal repetition at one end of the genome is not influenced by the orientation at the other end, and there are no labeled terminal fragments that corresponded both to those generated from termini of a normal double helical structure and those generating from an aberrant terminal secondary structure.
Journal of General VirologyMaturation of Parvovirus LuIII in a Subcellular System. I. Optimal Conditions for in vitro Synthesis and Encapsidation of Viral DNA
40 Citations1983D. Müller, G. Siegl
The development of an in vitro system prepared by lysis of LuIII virus-infected cells with Brij-58 has enabled the study of the assembly pathway of a parvovirus.
IntervirologyParvoviridae: Second Report
39 Citations1979Peter Bachmann, David Hoggan +5 more
An important finding for rapid classification is the demonstration of a common FA polypeptide antigen in the genus Adeno-associated virus, which is shared by all AAVs [8].
Journal of VirologyAutonomous parvovirus LuIII encapsidates equal amounts of plus and minus DNA strands
38 Citations1984Robert C. Bates, Cathrine E. Snyder +2 more
It is suggested that strand specificity of viral DNA encapsidation is not a useful property for differentiation between the autonomous and defective parvoviruses.
Journal of VirologyAnalysis of the termini of the DNA of bovine parvovirus: demonstration of sequence inversion at the left terminus and its implication for the replication model
35 Citations1988K C Chen, B C Shull +3 more
Replicative-form DNA showed the same distribution of terminal-sequence orientations as the reannealed plus and minus virion DNAs, suggesting that the distribution of flip and flop forms observed in virion DNA is not due to selective encapsidation, but rather to the specific distribution of replicative forms.
NatureConjecture on the Spread of Infection in Two Dimensions Disproved
35 Citations1972Denis Mollison
Comparison with a simple epidemic model shows that the velocity of expansion is bounded, and hence that the conjecture about the spread of abnormal cells through a plane lattice is false.
Journal of VirologyGenomic clones of bovine parvovirus: construction and effect of deletions and terminal sequence inversions on infectivity
27 Citations1988B C Shull, K C Chen +3 more
Analysis of low-molecular-weight DNA isolated from lysates of cells transfected with these clones demonstrated that rescue and replication of BPV DNA could be detected 3 to 8 days after transfection, and end-label analysis showed that the 34-base deletion was repaired to wild-type length in the progeny virus.
Journal of VirologyIdentical ends are not required for the equal encapsidation of plus- and minus-strand parvovirus LuIII DNA
25 Citations1989Nanette Diffoot, B C Shull +4 more
The sequence data for LuIII virus demonstrate that identical termini are not required for this encapsidation pattern, and the termini shared a high degree of sequence homology.
