Review: Granulocyte Colony-Stimulating Factor--Role and Relationships in Infectious Diseases
The Journal of Infectious DiseasesPublished 1 October 1995
David C. Dale, W. Conrad Liles, W. R. Summer, Steve Nelson
Citations231
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Three important observations in the 1960s set the stage for the appreciation of the importance of the hematopoietic growth factors, called colony-stimulating factors, in regulating the neutrophil response in infectious diseases, and were critical to the development of the understanding of the role of neutrophils in host defenses.
Abstract
Journal Article Review: Granulocyte Colony-Stimulating Factor—Role and Relationships in Infectious Diseases Get access David C. Dale, David C. Dale Reprints or correspondence: Dr. David C. Dale, Dept. of Medicine, University of Washington, Box 356422, Seattle, WA 98195. Search for other works by this author on: Oxford Academic PubMed Google Scholar W. Conrad Liles, W. Conrad Liles Search for other works by this author on: Oxford Academic PubMed Google Scholar Warren R. Summer, Warren R. Summer Search for other works by this author on: Oxford Academic PubMed Google Scholar Steve Nelson Steve Nelson Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Infectious Diseases, Volume 172, Issue 4, October 1995, Pages 1061–1075, https://doi.org/10.1093/infdis/172.4.1061 Published: 01 October 1995 Article history Received: 21 March 1995 Revision received: 30 May 1995 Published: 01 October 1995
Keywords
Immunology and MicrobiologyBiochemistry, Genetics and Molecular Biology
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Granulocyte mobilization into skin abrasions in human volunteers was significantly inhibited by acute alcohol intoxication, and protection of the abrasion against heat loss did not reduce the inhibited delivery in intoxicated volunteers.
Life SciencesAlcohol suppresses lipopolysaccharide-induced tumor necrosis factor activity in serum and lung
112 Citations1989Steve Nelson, Gregory Bagby +1 more
The anti-inflammatory effects of ethanol may be secondary to suppression of macrophage-derived tumor necrosis factor, which mediates the inflammatory cascade and stimulates phagocyte functions.
The Journal of ImmunologyAntibody-dependent cellular cytotoxicity-inducing antibodies against human immunodeficiency virus. Presence at different clinical stages.
112 Citations1987K Ljunggren, Blenda Böttiger +4 more
The presence of antibodies mediating antibody-dependent cellular cytotoxicity (ADCC) against human immunodeficiency virus (HIV)-infected target cells was investigated with 170 sera from patients with varying severity of HIV infection, and the possible beneficial effect of ADCC-inducing antibodies early in infection is discussed.
BloodEffects of gamma-interferon on human neutrophils: protection from deterioration on storage
102 Citations1992SJ Klebanoff, S Olszowski +4 more
Findings suggest that storage of PMN in a functionally active state is favored by the presence of IFN-gamma, and the decline in the staphylocidal activity of the stored PMN was prevented in part by IFN -gamma.
The American Journal of the Medical SciencesALCOIIOL AS A FACTOR IN THE ILLNESS OF UNIVERSITY SERVICE PATIENTS
99 Citations1965James Nolan
A prospective study was conducted by the Medical House Staff of the Grace-New Haven Community Hospital in order to assess the magnitude of the role of alcohol in the illnesses of patients admitted to general medical wards, finding that one admission out of 10 is directly related to the abuse of alcohol.
American Review of Respiratory DiseaseGranulocyte Colony-stimulating Factor Does Not Enhance Endotoxin-induced Acute Lung Injury in Guinea Pigs
97 Citations1992Minoru Kanazawa, Akitoshi Ishizaka +3 more
Pretreatment with G-CSF tended to attenuate rather than enhance neutrophil-dependent acute lung responses to endotoxin, which was similar to that in the CPA+endotoxin group.
Surgical Clinics of North AmericaThe Immune Consequences of Trauma
94 Citations1982Susan Miller, Carol Miller +1 more
This articles provides an overview of current knowledge of trauma-mediated alterations of host defense mechanisms and their implications for clinical practice.
Archives of SurgeryProtective Effect of Recombinant Human Granulocyte Colony-Stimulating Factor Against Pneumococcal Infections in Splenectomized Mice
93 Citations1990James C. Hebert
The recombinant human granulocyte colony-stimulating factor (rhG-CSF) may be a useful adjuvant for treating infections in individuals with immunologic dysfunctions other than neutropenia.
Clinical Infectious DiseasesModulation of Host Defenses by Cytokines: Evolving Adjuncts in Prevention and Treatment of Serious Infections in Immunocompromised Hosts
93 Citations1992Emmanuel Roilides, P. A. Pizzo
Preclinical and clinical studies of cytokines in immunocompromised hosts suggest that certain cytokines can accelerate neutrophil and monocyte/macrophage production, enhance their function, and potentially decrease infectious complications.
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