Brain Metabolism in Teenagers With Attention-Deficit Hyperactivity Disorder
Archives of General PsychiatryPublished 1 May 1993
Alan J. Zametkin
Citations351
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Positron emission tomography scans can be performed and are well tolerated by normal teenagers and teenagers with ADHD and global or absolute measures of metabolism did not statistically differentiate between normal adolescents with ADHD.
Abstract
Global or absolute measures of metabolism using positron emission tomography and fludeoxyglucose F18 did not statistically differentiate between normal adolescents with ADHD. Positron emission tomography scans can be performed and are well tolerated by normal teenagers and teenagers with ADHD. The feasibility of normal minors participating in research involving radiation was established.
Keywords
MedicineNeuroscience
Manual for the State-Trait Anxiety Inventory
25,350 Citations1970Charles D. Spielberger, Richard L. Gorsuch +1 more
Journal of Abnormal Child PsychologyNormative data on Revised Conners Parent and Teacher Rating Scales
1,730 Citations1978Charles H. Goyette, C. Keith Conners +1 more
Normative data are presented for 570 children on newly revised versions of the Conners Parent and Teacher Rating Scales, found to be significant determinants of children 's scores, while social class effects were nonsignificant.
Annals of NeurologyPositron emission tomography study of human brain functional development
1,557 Citations1987Harry T. Chugani, Michael E. Phelps +1 more
The determination of changing metabolic patterns accompanying normal brain development is a necessary prelude to the study of abnormal brain development with positron emission tomography.
New England Journal of MedicineCerebral Glucose Metabolism in Adults with Hyperactivity of Childhood Onset
981 Citations1990Alan J. Zametkin, Thomas Nordahl +6 more
The hypothesis that cerebral glucose metabolism might differ between normal adults (controls) and adults with histories of hyperactivity in childhood who continued to have symptoms after treatment with stimulant medication is investigated.
Journal of Abnormal Child PsychologyDevelopment of a structured psychiatric interview for children: Agreement between child and parent on individual symptoms
949 Citations1982Barbara Herjanic, Wendy Reich
To test the reliability of children's reporting as compared with that of their mothers, a highly structured psychiatric diagnostic interview was used with 307 subjects, ages 6 through 16.
American Journal of Physiology-Endocrinology and MetabolismNoninvasive determination of local cerebral metabolic rate of glucose in man
931 Citations1980S.C. Huang, M. E. Phelps +4 more
The rate constants of FDG in man were found to be comparable to those of deoxyglucose in rat and in rhesus monkey and the subject-to-subject variation of LCMRGlc as measured by the present method was comparable to that of other methods that measure whole-brain CMRglc.
ScienceMaturational Changes in Cerebral Function in Infants Determined by <sup>18</sup> FDG Positron Emission Tomography
670 Citations1986Harry T. Chugani, Michael E. Phelps
Functional changes measured with positron emission tomography in human infants during development are in agreement with behavioral, neurophysiological, and anatomical alterations known to occur during infant development.
Archives of NeurologyStriatal Dysfunction in Attention Deficit and Hyperkinetic Disorder
550 Citations1989H. Lou, L. Henriksen +3 more
Low striatal activity, partially reversible with methylphenidate, appears to be a cardinal feature in ADHD.
Archives of NeurologyFocal Cerebral Hypoperfusion in Children With Dysphasia and/or Attention Deficit Disorder
496 Citations1984H. C. Lou, L. Henriksen +1 more
The location of hypoperfused structures in cognitive disorders of childhood is consistent with a role for an early hypoxic-ischemic event in their origin.
Journal of Abnormal Child PsychologyThe ecological validity of laboratory and analogue assessment methods of ADHD symptoms
425 Citations1991Russell A. Barkley
It is concluded that future advances in ecological validity are likely to come from a greater reliance on assessments of the target behaviors in natural settings and combining several of the more promising tasks and analogue methods into a battery that is taken over longer time intervals than has been customary and averaged across repeated administrations.
Archives of General PsychiatryA Controlled Family Study of Chronic Psychoses
344 Citations1988Elliot S. Gershon
There was no tendency for schizoaffective diagnosis or acute psychoses to aggregate separately from schizophrenia, and there were not significant differences in the number of relatives with nonbipolar psychoses.
Archives of NeurologyFailure to Activate the Left Temporoparietal Cortex in Dyslexia
290 Citations1992Judith M. Rumsey
Dyslexic men failed to activate those left temporoparietal regions activated in controls during rhyme detection but did not differ from controls in these regions during rest or attentional testing, demonstrated only when specific probes for these regions were employed.
NeurologyTomographic mapping of human cerebral metabolism
240 Citations1981Michael E. Phelps, John C. Mazziotta +5 more
The interictal state of a patient with visual seizures demonstrated a hypometabolic visual cortex with a 2.5-fold increase in metabolism during an ictal visual hallucination.
The LancetFocal cerebral dysfunction in developmental learning disabilities
224 Citations1990H. Lou
In 24 children with developmental learning disabilities and 15 age-matched controls regional cerebral activity was studied with xenon-133 single photon emission tomography, abnormal--low in striatal and posterior periventricular regions and high in occipital regions was seen in 9 children with pure attention deficit and hyperactivity disorder.
PubMedAlternative formula for glucose utilization using labeled deoxyglucose.
208 Citations1982Rodney A. Brooks
A new formula for calculating the metabolic rate of glucoseutilization using labelled deoxyglucose (C-14 or F- 18) from tissue concentration oftracer is presented.
PubMedA method for postinjection PET transmission measurements with a rotating source.
119 Citations1988Richard E. Carson, Margaret E. Daube-Witherspoon +1 more
Applications of the technique can significantly shorten the time between transmission and emission studies, and thereby reduce the likelihood of patient motion and increase scanning throughput.
PubMedThe radiation dosimetry of 2 [F-18]fluoro-2-deoxy-D-glucose in man.
106 Citations1982Stephen C. Jones, Abass Alavi +4 more
These time-activity measurements for the critical organ in the human avoid the assumptions made in using animal biodistribution data for human dosimetry calculations.
Journal of the American Academy of Child & Adolescent PsychiatryEffects of Methylphenidate on Adolescents with Aggressive Conduct Disorder and ADDH: A Preliminary Report
99 Citations1990Stuart L. Kaplan, Joan Busner +3 more
The effect of methylphenidate on aggression in adolescents diagnosed with both aggressive conduct disorder and attention deficit disorder with hyperactivity was assessed in nine male adolescents using a placebo controlled double-blind design.
Journal of the American Academy of Child & Adolescent PsychiatryClinical Effects of a Controlled Trial of Methylphenidate on Adolescents with Attention Deficit Disorder
84 Citations1990Rafael Klorman, Joan T. Brumaghim +2 more
The results support the continued effectiveness of stimulant therapy for attention deficit disorder in adolescence, however, the magnitude of clinical effectiveness reported was smaller than previously found in younger patients.
Brain and DevelopmentBrain glucose metabolism in children with the autistic syndrome: Positron tomography analysis
74 Citations1987Anne De Volder, Anne Bol +3 more
Data suggest that both the rate and the regional distribution of brain glucose metabolism are normal in autistic children, and variations in terms of relative metabolic rates in association cortex remains to be investigated further.
PubMed[Study of cerebral blood flow by the xenon-133 method in 10 schizophrenic adolescents].
1 Citations1985Henri Chabrol, A Güell +1 more
Regional cerebral blood flow was compared in adolescents with hebephrenia who were never treated with neuroleptics and normal controls using the Xenon 133 inhalation method and the main difference was the loss of the "hyperfrontal pattern" in the schizophrenics.