Suppression of macrophage reactive intermediates by cocaine
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TL;DR
Cocaine inhibited NO2- production only in vitro, failing to suppress it through in vivo administration, and hydrogen peroxide and superoxide productions were suppressed by both in vitro treatments and in vivo administrations of cocaine.
Abstract
The in vivo or in vitro effects of cocaine on the production of hydrogen peroxide (H2O2), superoxide (O2-), and nitrite (NO2-) by sodium periodate-elicited macrophages were studied. Hydrogen peroxide and superoxide productions were suppressed by both in vitro treatments and in vivo administrations of cocaine. The H2O2 and O2- production partially recovered after 150 min in vitro. However, cocaine inhibited NO2- production only in vitro, failing to suppress it through in vivo administration.