Hormonally regulated α4β2δ GABAA receptors are a target for alcohol
Nature NeurosciencePublished 15 July 2002Open access
Inger Sundström Poromaa, Deborah H. Smith, Qi Hua Gong, Thomas N. Sabado, Xinshe Li, Adam Light
Citations326
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TL;DR
Low concentrations of alcohol increased Cl− currents gated by a recombinant GABAA receptor, α4β2δ, by 40–50% in Xenopus laevis oocytes, and greater hippocampal expression of receptors containing α4 and δ subunits is found.
Abstract
Here we report that low concentrations of alcohol (1-3 mM) increased Cl(-) currents gated by a recombinant GABA(A) receptor, alpha(4)beta(2)delta, by 40-50% in Xenopus laevis oocytes. We also found greater hippocampal expression of receptors containing alpha(4) and delta subunits, using a rat model of premenstrual syndrome (PMS) in which 1-3 mM alcohol preferentially enhanced GABA-gated currents, and low doses of alcohol attenuated anxiety and behavioral reactivity. The alcohol sensitivity of delta-containing receptors may underlie the reinforcing effects of alcohol during PMS, when eye saccade responses to low doses of alcohol are increased.
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Neuroscience
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