CSF hypocretin levels in Guillain–Barre syndrome and other inflammatory neuropathies
NeurologyPublished 23 September 2003
Setsu Nishino, Takashi Kanbayashi, Nobuhiro Fujiki, Makoto Uchino, Beth Ripley, Mamoru Watanabe
Citations97
SJR quartileQ1
SJR score2.40
SNIP1.82
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TL;DR
CSF hypocretin-1 was measured in 28 Guillain–Barré syndrome (GBS), 12 Miller–Fisher syndrome, 12 chronic inflammatory demyelinating polyneuropathy (CIDP), and 48 control subjects to identify low levels in GBS that were associated with upper CNS level abnormalities.
Abstract
CSF hypocretin-1 was measured in 28 Guillain-Barré syndrome (GBS), 12 Miller-Fisher syndrome, 12 chronic inflammatory demyelinating polyneuropathy (CIDP), and 48 control subjects. Seven GBS subjects had undetectably low hypocretin-1 levels (<100 pg/mL). Hypocretin-1 levels were moderately reduced in an additional 11 GBS, 5 Miller-Fisher syndrome, and 1 CIDP subject. Low levels in GBS occurred early in the disease and were associated with upper CNS level abnormalities.
Keywords
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