Sex differences in dopamine receptor overproduction and elimination

NeuroreportPublished 1 April 1997

Susan L. Andersen, Mark Rutstein, J Benzo, John C. Hostetter, Martin H. Teicher

DOI10.1097/00001756-199704140-00034

Source URL

Citations318

SJR quartileQ3

SJR score0.49

SNIP0.39

TL;DR

Males had more extensive overproduction of D1 receptors in nucleus accumbens and sustained a greater density into adulthood than females, which has implications for understanding gender differences in the prevalence of clinical disorders associated with dopamine.

Abstract

Density of dopamine D1 and D2 family receptors was assessed using autoradiography in male and female rats from 25 to 120 days of age, focusing on transitions through puberty into full adulthood. Males had greater overproduction (approximately 4.6-fold) and elimination of striatal D1 and D2 receptors than females, though their adult densities were very similar. Males had more extensive overproduction of D1 receptors in nucleus accumbens and sustained a greater density into adulthood (57.8 +/- 21.2%). These results have implications for understanding gender differences in the prevalence of clinical disorders associated with dopamine.

Keywords

PsychologyNeuroscience

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