Gamma-carboxyglutamate in a neuroactive toxin.
Journal of Biological ChemistryPublished 1 December 1984Open access
J. Michael McIntosh, Baldomero M. Olivera, Lourdes J. Cruz, William R. Gray
Citations202
SJR quartileQ1
SJR score1.71
SNIP1.00
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TL;DR
The venom of a fish-hunting cone snail contains a novel toxin, the "sleeper" peptide, which induces a sleep-like state in mice when injected intracerebrally, and it is demonstrated that this peptide contains 5 mol of gamma-carboxyglutamate (Gla) in 17 amino acids.
Abstract
The venom of a fish-hunting cone snail (Conus geographus) contains a novel toxin, the "sleeper" peptide, which induces a sleep-like state in mice when injected intracerebrally. We demonstrate that this peptide contains 5 mol of gamma-carboxyglutamate (Gla) in 17 amino acids. The amino acid sequence of the sleeper peptide is Gly-Glu-Gla-Gla-Leu-Gln-Gla-Asn-Gln-Gla-Leu-Ile-Arg-Gla-Lys-Ser-Asn-NH2.
Keywords
NeuroscienceBiochemistry, Genetics and Molecular Biology
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