Association of the Length Polymorphism in the Human Per3 Gene with the Delayed Sleep-Phase Syndrome: Does Latitude Have an Influence Upon It?
SLEEPPublished 1 January 2005Open access
Danyella Silva Pereira, Sérgio Tufik, Fernando Mazzilli Louzada, Ana Amélia Benedito‐Silva, Alberto Remesar Lopez, Nelson A. M. Lemos
Citations213
SJR quartileQ1
SJR score1.80
SNIP1.63
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TL;DR
The results suggest that latitude has a role in the influence of hPer3 gene polymorphism on delayed sleep-phase syndrome and confirm previous data showing its association with morningness-eveningness tendencies.
Abstract
STUDY OBJECTIVES: The objective of this study is to analyze the influence of a previously reported hPer3 gene-length polymorphism in the delayed sleep-phase syndrome and in morningness-eveningness tendencies at low latitudes in the southern hemisphere. DESIGN: We have genotyped a length polymorphism in the hPer3 gene characterized by a short repeat allele (4-repeat) and a long repeat allele (5-repeat). PARTICIPANTS: Seventeen patients with delayed sleep-phase syndrome; 156 volunteers chosen according to Horne-Ostberg questionnaire to have morning, intermediate, or evening preference; and 110 volunteers with no Horne-Ostberg score as a sample of the general population. RESULTS: We have found a higher frequency of 5-repeat allele in the delayed sleep-phase syndrome group and an association of this polymorphism with diurnal preference. CONCLUSION: Our results suggest that latitude has a role in the influence of hPer3 gene polymorphism on delayed sleep-phase syndrome and confirm previous data showing its association with morningness-eveningness tendencies.
Keywords
PsychologyNeuroscience
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