Suprachiasmatic nucleus transplants function as an endogenous oscillator only in constant darkness
Neuroscience LettersPublished 1 August 1986
Raúl Aguilar‐Roblero, Fernando García‐Hernández, R Guevara Aguilar, Gloria Arankowsky‐Sandoval, René Drucker‐Colín
Citations31
SJR quartileQ2
SJR score0.77
SNIP0.67
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Rats which sustained lesions of the suprachiasmatic nucleus were transplanted with fetal hypothalamic tissue which included the SCN and the results suggest that the grafted tissue functions as a self-sustained oscillator only in darkness.
Abstract
Rats which sustained lesions of the suprachiasmatic nucleus (SCN) were transplanted with fetal hypothalamic tissue which included the SCN. After the graft, animals were kept under a 12:12 light-dark (LD) cycle during 6 weeks at which time half the animals were placed in constant light (LL) and half in constant darkness (DD). The results showed that all grafted rats recovered the photoperiod under LD, but under constant conditions rats began to free-run only in DD. The results suggest that the grafted tissue functions as a self-sustained oscillator only in darkness.
Keywords
PsychologyNeuroscience
Brain ResearchLoss of a circadian adrenal corticosterone rhythm following suprachiasmatic lesions in the rat
2,108 Citations1972Robert Y. Moore, Victor B. Eichler
The purpose of the present study was to reinvestigate the role of the central retinal projections in neuroendocrine regulation and find that lesions in the suprachiasmatic region of the hypothalamus abolish the constant estrous response to light in the female rat.
Proceedings of the National Academy of SciencesCircadian Rhythms in Drinking Behavior and Locomotor Activity of Rats Are Eliminated by Hypothalamic Lesions
2,015 Citations1972Friedrich K. Stephan, Irving H. Zucker
Bilateral electrolytic lesions in the suprachiasmatic nuclei permanently eliminated nocturnal and circadian rhythms in drinking behavior and locomotor activity of albino rats.
Proceedings of the National Academy of SciencesPersistence of circadian rhythmicity in a mammalian hypothalamic "island" containing the suprachiasmatic nucleus.
984 Citations1979Sachiye Inouye, Hiroshi Kawamura
Simultaneous recording from two extracellular electrodes indicated neural activity at two sites in the brain, one of which is in or near the suprachiasmatic nucleus and the other in one of many other brain locations, which indicated clear circadian rhythmicity of spontaneous neural activity.
PubMedOrganization and function of a central nervous system circadian oscillator: the suprachiasmatic hypothalamic nucleus.
688 Citations1983Moore Ry
It is concluded from available data that the suprachiasmatic hypothalamic nuclei (SCN) are the principal circadian oscillators in the rodent brain and that a retinohypothalamic projection terminating in the SCN is the primary visual pathway subserving entrainment of circadian rhythms.
Brain ResearchCircadian rhythm of firing rate recorded from single cells in the rat suprachiasmatic brain slice
502 Citations1982Daniel J. Green, Rhanor Gillette
Brain slices, containing the suprachiasmatic nuclei, of rats were removed at various times of the fay and the firing rates of single cells were recorded and found to maintain a circadian rhythm in temporal accord with the light/dark cycle of the donor animal.
Zeitschrift für TierpsychologieCircadian Rhythms: Influences of Internal and External Factors on the Period Measured in Constant Conditions1
477 Citations2010Jürgen Aschoff
Most of the data available on the period of freerunning circadian rhythms, measured in constant conditions, are reviewed, with emphasis on the effects of light intensity and ambient temperature on ẗ.
Journal of NeuroscienceImmunocytochemical localization of vasoactive intestinal polypeptide- containing cells and processes in the suprachiasmatic nucleus of the rat: light and electron microscopic analysis
346 Citations1981J. Patrick Card, Nicholas C. Brecha +2 more
The demonstration of VIP-containing neurons in the SCN provides further evidence that this nucleus is composed of a heterogeneous population of neurons which form distinct subfields within it.
Brain ResearchCircadian rhythmic changes of neuronal activity in the suprachiasmatic nucleus of the rat hypothalamic slice
279 Citations1982Shigenobu Shibata, Yutaka Oomura +2 more
The Journal of Comparative Neurology<i>In vivo</i> metabolic activity of a putative circadian oscillator, the rat suprachiasmatic nucleus
229 Citations1980William J. Schwartz, Leslie Davidsen +1 more
These experiments indicate an important role for the SCN in circadian rhythm organization, and it is believed the deoxyglucose method will prove useful as a tool for better understanding the functions and mechanisms of circadian clocks.
Journal of Comparative Physiology ACharacteristics of a circadian pacemaker in the suprachiasmatic nucleus
218 Citations1982S.-I.T. Inouye, Hiroshi Kawamura
The results suggest an endogenous nature of the circadian rhythm of the SCN within the hypothalamic island, which may have not only an inherent ability to generate a circadian rhythm, but also an intricate machinery to regulate its phase.
Cell and Tissue ResearchImmunocytochemical localization of somatostatin-containing neurons in the rat hypothalamus
161 Citations1979Karen Dierickx, Frans Vandesande
The rat hypothalamus was studied at the light microscopic level with the use of single and double immunocytochemical staining methods and it was shown that the rat supraoptic and paraventricular hypothalamic nuclei, and their accessory neurosecretoryuclei, do not contain magnocellular somatostatin neurons.
Brain ResearchFetal suprachiasmatic nucleus transplants: diurnal rhythm recovery of lesioned rats
161 Citations1984René Drucker‐Colín, Raúl Aguilar‐Roblero +3 more
The results show that grafts allow animals to recover lost functional properties due to lesions, and further support the notion that the SCN is a pacemaker for certain behaviors.
Neuroscience ResearchTransplantation of the neonatal suprachiasmatic nuclei into rats with complete bilateral suprachiasmatic lesions
157 Citations1984Y. Sawaki, Itsuko Nihonmatsu +1 more
Findings suggest that the recovery of circadian rhythmicity was the result of functional reinnervation of the periventricular zone by efferent fibers from the SCN.
Brain ResearchIn vivo metabolic activity of the suprachiasmatic nuclei: a comparative study
153 Citations1983William J. Schwartz, Steven M. Reppert +2 more
Physiology & BehaviorCircadian temperature and wake rhythms of rats exposed to prolonged continuous illumination
139 Citations1983Charmane I. Eastman, Allan Rechtschaffen
Although the data did not rule out control by separate circadian oscillators, one for temperature and one for wake, a single oscillator model was sufficient to explain this phenomenon and suggested a causal relationship between temperature and sleep and circadian arrhythmicity.
ScienceSuprachiasmatic Stimulation Phase Shifts Rodent Circadian Rhythms
137 Citations1982Benjamin Rusak, G. A. Groos
Findings strengthen the hypothesis derived from lesion studies that the SCN are the dominant light-entrained oscillators in the rodent circadian system.
American Journal of Physiology-Regulatory, Integrative and Comparative PhysiologyEndogenous ultradian rhythms in rats exposed to prolonged continuous light
118 Citations1978Ken‐ichi Honma, Tsutomu Hiroshige
The results suggest that the ultradian component, manifested under prolonged continuous light, is a fundamental unit of the circadian rhythm and an oscillator for the Ultradian rhythm is common to the three functions examined.
Brain ResearchDoes the ventromedial hypothalamic nucleus contain a self-sustained circadian oscillator associated with periodic feedings?
58 Citations1983Shin‐Ichi T. Inouye
Although the VMH is involved in the synchronization of rhythms to periodic feeding, the present results indicate that, unlike the SCN which contains an oscillator associated with light, theVMH does not contain another self-sustained oscillators associated with food.
NeuroscienceVasopressin neuron survival in neonatal Brattleboro rats; critical factors in graft development and innervation of the host brain
27 Citations1985Gerard J. Boer, Don M. Gash +2 more
The failure of the grafts to provide adequate vasopressinergic innervation of the host median eminence probably explains why none of the nearly 200 Brattleboro neonates operated upon showed any sign of relief of their diabetes insipidus.