Activities of cholic acid-derived antimicrobial agents against multidrug-resistant bacteria

Journal of Antimicrobial ChemotherapyPublished 1 May 2001Open access

Erica J. Schmidt, John S. Boswell, James P. Walsh, Maja Schellenberg, T W Winter, Chao Li

DOI10.1093/jac/47.5.671

Source URL

Citations56

SJR quartileQ1

SJR score1.21

SNIP1.12

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TL;DR

Cationic cholic acid derivatives displayed potent and broad-spectrum activity against multidrug-resistant Gram-negative and -positive bacteria and sensitized these to hydrophobic antibiotics.

Abstract

Cationic cholic acid derivatives displayed potent and broad-spectrum activity against multidrug-resistant Gram-negative and -positive bacteria. Specific examples were effective permeabilizers of the outer membranes of many strains of multidrug-resistant Gram-negative bacteria and sensitized these to hydrophobic antibiotics. We also prepared a new cholic acid derivative with improved apparent selectivity for prokaryote membranes.

Keywords

Immunology and MicrobiologyBiochemistry, Genetics and Molecular Biology

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