STUDIES IN IRON TRANSPORTATION AND METABOLISM. IV. OBSERVATIONS ON THE ABSORPTION OF IRON FROM THE GASTRO-INTESTINAL TRACT 12
Journal of Clinical InvestigationPublished 1 September 1939Open access
Carl V. Moore, Wm. R. Arrowsmith, Jo M. Welch, Virginia Minnich
Citations105
SJR quartileQ1
SJR score4.72
SNIP2.17
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TL;DR
Most of the problems of iron therapy which have troubled physicians during the past half century are fundamentally traceable to the authors' ignorance of the mechanism by which iron is absorbed from the intestinal tract.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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A growing interest in the mechanism by which iron is transported in the blood stream has been stimulated by the desire to understand more fully this essential phase of iron metabolism in the mammalian body.
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The results of studies of patients with hypochromic anemia who were given large amounts of iron by mouth who recover after the administration of massive doses of iron are presented.
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Until more is known of the mechanisms involved in different types of anemia, in man and animals, the statement of Witts is much to the point, namely, that no apology is needed for considering the field of clinical medicine the testing ground of iron therapy.
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Fig. 10. Dasselbe~ wie bei Fig. 9, aach 32 Tagen: a} Stichcanal mit einer schmale~l Zone nekrotischen Gewebes; b)ganz ausgebildete Narbe; c) tocker-faseriges Bindeg'ewebe; d) Muskelgewebe mit Bindegewe be darchsetzt (B., Oc.
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In patients with depletion of stored iron due to a bleeding ulcer, dietary iron alone is insufficient to stimulate rapid formation of hemoglobin, and chronic anemia often persists after the bleeding is stopped.
QJMTHE FATE OF LARGE DOSES OF IRON ADMINISTERED BY MOUTH<xref ref-type="fn" rid="fn1"><sup>1</sup></xref>
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It is thus of interest to inquire whether other factors may be lacking besides iron and, if so, whether these factors when supplied can assist in the formation of hemoglobin.
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13 Citations1937W. M. Fowler
The hemoglobin response to small amounts of iron has been found to be less satisfactory, although the amount of iron would seem to be adequate for hemoglobin regeneration if it were properly absorbed from the gastro-intestinal tract.
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9 Citations1934Harold W. Fullerton
Results in the treatment of secondary anaemias daily of s,chloride and ferrous sulphate in doses of 1 grains favour * small dosage does not seem to have found much.
Experimental Biology and MedicineAbsorption of Iron Compounds from the Upper Part of the Small Intestine
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