A proliferation of cyclins
Trends in Cell BiologyPublished 1 March 1992
Daniel J. Lew, Steven I. Reed
Citations82
SJR quartileQ1
SJR score5.46
SNIP2.93
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TL;DR
What is known about the functions of the nonmitotic cyclins in yeast and in mammalian cells is reviewed.
Abstract
Cyclins are regulatory subunits of the serine/threonine protein kinases that play key roles in cell cycle control. The roster of known cyclins has expanded significantly in the past year, revealing a large and very diverse family of proteins. Although cyclins were originally characterized by their periodic accumulation during interphase and destruction in mitosis (these were the 'mitotic' cyclins that control entry into mitosis), the newly identified cyclins do not conform to this pattern. Here we review what is known about the functions of the nonmitotic cyclins in yeast and in mammalian cells.
Keywords
Biochemistry, Genetics and Molecular Biology
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