Extracellular tumor necrosis factor induces a decreased K+ conductance in an identified neuron of Aplysia kurodai
Neuroscience LettersPublished 1 July 1990
Masashi Sawada, Nobumasa Hara, Takashi Maéno
Citations39
SJR quartileQ2
SJR score0.77
SNIP0.67
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TL;DR
Ion substitution and pharmacological experiments suggest that ITNF is due to a decreased K+ conductance and that TNF, a product of macrophages, may form an important link in communications between nervous and immune systems.
Abstract
Recombinant human tumor necrosis factor (rhTNF) was pressure-applied onto the the soma of identified neuron R12 in the Aplysia abdominal ganglion. rhTNF induced a slow inward current (ITNF, 80-100 s in duration, 5-10 nA in amplitude) associated with a conductance decrease. ITNF begins 1-2 s after applying rhTNF and peaks in 5-6 s. ITNF was decreased by hyperpolarization and had a reversal potential of approximately -87 mV (close to the K+ equilibrium potential). Ion substitution and pharmacological experiments suggest that ITNF is due to a decreased K+ conductance and that TNF, a product of macrophages, may form an important link in communications between nervous and immune systems.
Keywords
NeuroscienceBiochemistry, Genetics and Molecular Biology
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