Long-term assessment of glucose control by haemoglobin-AGE measurement
The LancetPublished 1 February 1996
Bruce H. R. Wolffenbuttel, Donna Giordano, Hank Founds, Richard Bucala
Citations122
SJR quartileQ1
SJR score12.11
SNIP22.72
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The observation that Hb-AGE declines more slowly than HbA1c is consistent with the irreversible nature of the AGE product, and may prove superior to Hb a1c as a long-term index of circulating glucose concentrations.
Abstract
The observation that Hb-AGE declines more slowly than HbA1c is consistent with the irreversible nature of the AGE product. Because of this property, Hb-AGE may prove superior to HbA1c as a long-term index of circulating glucose concentrations.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
Journal of Biological ChemistryPROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
318,326 Citations1951OliverH. Lowry, NiraJ. Rosebrough +2 more
Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
New England Journal of MedicineThe Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus
24,537 Citations1993David M. Nathan
Intensive therapy effectively delays the onset and slows the progression of diabetic retinopathy, nephropathy, and neuropathy in patients with IDDM.
New England Journal of MedicineAdvanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications
2,518 Citations1988Jeffrey S. Flier, Lisa H. Underhill +3 more
This seminar reviews recent studies suggesting that the central pathologic features of diabetic complications are caused by the hyperglycemia-accelerated formation of nonenzymatic advanced gly...
New England Journal of MedicineCorrelation of Glucose Regulation and Hemoglobin A<sub>Ic</sub>in Diabetes Mellitus
1,164 Citations1976Ronald J. Koenig, Charles M. Peterson +4 more
The periodic monitoring of hemoglobin AIc levels provides a useful way of documenting the degree of control of glucose metabolism in diabetic patients and provides a means whereby the relation of carbohydrate control to the development of sequelae can be assessed.
New England Journal of MedicineThe Clinical Information Value of the Glycosylated Hemoglobin Assay
706 Citations1984David M. Nathan, Daniel E. Singer +2 more
It is concluded that the glycosylated hemoglobin assay provides information about the degree of long-term glucose control that is not otherwise obtainable in the usual clinical setting.
Proceedings of the National Academy of SciencesAccelerated age-related browning of human collagen in diabetes mellitus.
674 Citations1984Vincent M. Monnier, Robert R. Kohn +1 more
Collagen adducts from aged and diabetic individuals had absorption and fluorescence spectra identical to those of collagen samples that underwent nonenzymatic browning with glucose in vitro, suggesting their likely occurrence throughout the body could explain the correlation between arterial stiffening, decreased joint mobility, and the severity of microvascular complications in type I diabetics.
New England Journal of MedicineRelation between Complications of Type I Diabetes Mellitus and Collagen-Linked Fluorescence
583 Citations1986Vincent M. Monnier, Vasanth Vishwanath +4 more
The data suggest that there is an overall correlation between the severity of diabetic complications and cumulative glycemia over many years.
Journal of Biological ChemistryImmunochemical detection of advanced glycosylation end products in vivo.
491 Citations1992Zenji Makita, Helen Vlassara +2 more
It is suggested that tissue AGEs which form in vivo appear to contain a common immunological epitope which cross-reacts with A GEs prepared in vitro, supporting the concept that immunologically similar AGE structures form from the incubation of sugars with different proteins.
Proceedings of the National Academy of SciencesModification of low density lipoprotein by advanced glycation end products contributes to the dyslipidemia of diabetes and renal insufficiency.
473 Citations1994Richard Bucala, Zenji Makita +5 more
Data indicate that AGE modification significantly impairs LDL-receptor-mediated clearance mechanisms and may contribute to elevated LDL levels in patients with diabetes or renal insufficiency.
Biochemical and Biophysical Research CommunicationsStudies of an unusual hemoglobin in patients with diabetes mellitus
393 Citations1969Samuel Rahbar, Olga O. Blumenfeld +1 more
Structural studies suggest the possibility that an amino sugar is bound to hemoglobin A1c in diabetic patients.
The Journal of Experimental MedicineEndothelial receptor-mediated binding of glucose-modified albumin is associated with increased monolayer permeability and modulation of cell surface coagulant properties.
383 Citations1989Ciro Esposito, Herwig Gerlach +3 more
The interaction of AGE- modified proteins with endothelium may play an important role in the early stages of increased vascular permeability, as well as vessel wall- related abnormalities of the coagulation system, characteristic of diabetes and aging.
Diabetes CareKinetics of HbA1c, Glycated Albumin, and Fructosamine and Analysis of Their Weight Functions Against Preceding Plasma Glucose Level
378 Citations1995Yasuhiro Tahara, Kenji Shima
The levels of HbA1c, GA, and FA do not reflect the simple mean but reflect the weighted mean of the preceding plasma glucose level over a considerably longer period than was previously speculated.
Proceedings of the National Academy of SciencesReceptor-specific increase in extracellular matrix production in mouse mesangial cells by advanced glycosylation end products is mediated via platelet-derived growth factor.
353 Citations1992Toshio Doi, Helen Vlassara +4 more
Evidence is shown that mouse mesangial cells exhibit an increase in collagen type IV mRNA and peptide synthesis after exposure to AGEs, suggesting that AGE formation in vivo may be one of the metabolic events leading to the development of diabetic glomerulosclerosis.
New England Journal of MedicineEffect of Long-Term Monitoring of Glycosylated Hemoglobin Levels in Insulin-Dependent Diabetes Mellitus
261 Citations1990Mogens Lytken Larsen, Mogens Hørder +1 more
Regular measurements of hemoglobin A1c lead to changes in diabetes treatment and improvement of metabolic control, indicated by a lowering of hemochemistry A1C values.
ScienceHemoglobin-AGE: A Circulating Marker of Advanced Glycosylation
253 Citations1992Zenji Makita, Helen Vlassara +6 more
Hb-AGE measurements may provide an index of long-term tissue modification by AGEs and prove useful in assessing the contribution of advanced glycosylation to a variety of diabetic and age-related complications.
DiabetesFormation of Immunochemical Advanced Glycosylation End Products Precedes and Correlates With Early Manifestations of Renal and Retinal Disease in Diabetes
246 Citations1995Paul J. Beisswenger, Zenji Makita +6 more
Levels of collagen-linked AGEs, when measured by an AGE-specific ELISA, reveal a correlation with preclinical stages of diabetic nephropathy and early retinopathy not indicated by other methods and may prove useful as early markers of microangiopathy in type I diabetes.
Annals of Internal MedicineReversible Hematologic Sequelae of Diabetes Mellitus
189 Citations1977Charles M. Peterson, ROBERT L. JONES +3 more
These studies found that certain secondary sequelas of diabetes can be corrected by strict carbohydrate control and confirmed that hemoglobin AIC assays provide a useful means of showing the degree of control of glucose metabolism in diabetic patients.
Proceedings of the National Academy of SciencesSynthesis of hemoglobin AIc in normal and diabetic mice: potential model of basement membrane thickening.
118 Citations1975Ronald J. Koenig, A Cerami
Adult diabetic mice (C57Bl/KsJ--db/db) have increased amounts of a minor hemoglobin in their peripheral blood compared to wild-type (+/+) mice, analogous to the 2-fold increase of a glycohemoglobin with similar chromatographic mobility seen in the blood of patients with diabetes mellitus.
PubMedThe chemistry of the Maillard reaction under physiological conditions: a review.
118 Citations1989F George Njoroge, Vincent M. Monnier
Past and current approaches to obtain clues on the chemical nature of Maillard products formed under physiological conditions are reviewed.
DiabetologiaTemporal relationship of glycosylated haemoglobin concentrations to glucose control in diabetics
104 Citations1979Peter J. Dunn, Richard Cole +6 more
While Hb AI provides an index of the control of diabetes, it appears to be more acutely responsive to blood glucose alteration than generally recognized.
Clinica Chimica ActaGlucosylation of human haemoglobin a in red blood cells studied in vitro. Kinetics of the formation and dissociation of haemoglobin A1c
79 Citations1983Henrik B. Mortensen, Carsten Christophersen
The emergence of haemoglobin A on saline incubation indicates that the non-enzymatic glucosylation of haenoglobin A to HbA1c is a reversible process, and should be of importance in interpretation of Hb a1c levels during abrupt changes in diabetic control.
Drug Development ResearchAdvanced glycosylation endproducts: Role in diabetic and non‐diabetic vascular disease
30 Citations1994Richard Bucala, Helen Vlassara +1 more
Protein‐bound and Lipid‐AGEs contribute to a variety of pathological effects in vivo by acting to increase vascular permeability, enhance subintimal protein and lipoprotein deposition, and exert direct toxic effects on endothelial cells.