Chain Migration of Neuronal Precursors
SciencePublished 16 February 1996
Carlos Lois, José Manuel García‐Verdugo, Arturo Álvarez-Buylla
Citations1,332
SJR quartileQ1
SJR score10.42
SNIP6.62
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Electron microscopic analysis of serial sections showed that during chain migration, neural precursors moved associated with each other and were not guided by radial glial or axonal fibers.
Abstract
In the brain of adult mice, cells that divide in the subventricular zone of the lateral ventricle migrate up to 5 millimeters to the olfactory bulb where they differentiate into neurons. These migrating cells were found to move as chains through a well-defined pathway, the rostral migratory stream. Electron microscopic analysis of serial sections showed that these chains contained only closely apposed, elongated neuroblasts connected by membrane specializations. A second cell type, which contained glial fibrillary acidic protein, ensheathed the chains of migrating neuroblasts. Thus, during chain migration, neural precursors moved associated with each other and were not guided by radial glial or axonal fibers.
Keywords
Neuroscience
The Journal of Cell BiologyJUNCTIONAL COMPLEXES IN VARIOUS EPITHELIA
3,617 Citations1963Marilyn G. Farquhar, George E. Palade
The tight junction is impervious to concentrated protein solutions and appears to function as a diffusion barrier or "seal," and the desmosome and probably also the zonula adhaerens may represent intercellular attachment devices.
ScienceLong-Distance Neuronal Migration in the Adult Mammalian Brain
2,313 Citations1994Carlos Lois, Arturo Álvarez-Buylla
Grafted and endogenous SVZ cells in the lateral ventricle of adult mice migrate long distances and differentiate into neurons in the olfactory bulb.
The Journal of Comparative NeurologyMode of cell migration to the superficial layers of fetal monkey neocortex
2,162 Citations1972Pasko Rakić
Golgi and electronmicroscopic methods were used to define the shapes and intercellular relationships of cells migrating from their sites of origin near the ventricular surface across the intermediate zone to the superficial neocortical layers of the parietooccipital region in the brains of 75‐ to 97‐day monkey fetuses.
NeuronRestricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone
1,794 Citations1993Maria B. Luskin
The SVZa appears to constitute a specialized source of neuronal progenitor cells that differentiated into granule cells and periglomerular cells of the olfactory bulb-the two major types of interneurons.
The Journal of Comparative NeurologyAutoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb
1,478 Citations1969Joseph Altman
The results established that the major target structure of cell production in the subependymal layer of the lateral ventricle in young‐adult rats is the olfactory bulb, with only moderate contribution made to the anterior neocortex and basal ganglia.
Brain ResearchLocalization of the glial fibrillary acidic protein in astrocytes by immunofluorescence
1,449 Citations1972A. Bignami, Lawrence F. Eng +2 more
The glial fibrillary acidic (GFA) protein, a brain specific protein extracted from severely gliosed human tissue, is not species specific; cross-reaction occurs between anti-human GFA protein antibodies and brain extracts of rabbit, guinea pig, rat and dog.
ScienceNeurogenesis in the Adult Rat: Electron Microscopic Analysis of Light Radioautographs
1,448 Citations1977Michael Kaplan, James W. Hinds
Three-month-old rats were injected intraperitoneally with [3H]thymidine and labeled cells in the granular layers of dentate gyrus and olfactory bulb were confirmed as neurons by electron microscopy of reembedded 1-micrometer sections.
International review of cytologyStructure and Function of Intercellular Junctions
1,333 Citations1974L. Andrew Staehelin
This chapter reviews the morphological information on intercellular junctions derived from thin-sectioning, negative staining and freeze-cleave techniques, as well as from x-ray diffraction and biochemical investigations, and correlates the structural parameters with known or proposed physiological functions.
NatureInactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning
1,010 Citations1994Harold Cremer, Rita Lange +11 more
It is shown here that N-CAM-deficient mice generated by gene targeting appear healthy and fertile, but adult mutants show a 10% reduction in overall brain weight and a 36% decline in size of the olfactory bulb.
Proceedings of the National Academy of SciencesNeuronal production, migration, and differentiation in a vocal control nucleus of the adult female canary brain.
983 Citations1983Steven A. Goldman, Fernando Nottebohm
It is concluded that neuronal precursors exist in the HVc ventricular zone that incorporate tritiated thymidine during the S phase preceding their mitosis; after division these cells migrate into, and to some extent beyond, HVm, which seems to be a normally occurring phenomenon in intact adult female canaries.
The Anatomical RecordEmbryonic vertebrate central nervous system: Revised terminology
727 Citations1970Jay Angevine, David Bodian +9 more
Anatomy and EmbryologyA golgi study of radial glial cells in developing monkey telencephalon: Morphogenesis and transformation into astrocytes
677 Citations1979Donald E. Schmechel, Pasko Rakić
Radial glial cells impregnated by a modified del Rio Hortega rapid Golgi method were studied in the occipital lobes of 38 rhesus monkeys from embryonic day 48 to birth which occurs at E165 and in 27 postnatal animals to day 365.
Cellular and Molecular Life SciencesPrinciples of neural cell migration
654 Citations1990Pasko Rakić
The present article considers the basic mechanisms and principles of neuronal cell migration in the mammalian central nervous system and considers surface-mediated interaction between neighboring cells.
The Journal of Cell BiologyA FINE STRUCTURAL ANALYSIS OF INTERCELLULAR JUNCTIONS IN THE MOUSE LIVER
623 Citations1970Daniel A. Goodenough, J P Revel
Acetone does not cause any detectable change in the structure of the zonula occludens, but the occluding junction becomes leaky to lanthanum following acetone treatment, and the effects of other reagents on the junctions are reported.
The Anatomical RecordAutoradiographic investigation of cell proliferation in the brains of rats and cats
613 Citations1963Joseph Altman
The results indicate that glia cells can multiply in the brains of young adult rats and adult cats and they support the possibility that new neurons may be formed in forebrain structures, both in rodents and carnivores.
ScienceNeurons in the Rat Dentate Gyrus Granular Layer Substantially Increase During Juvenile and Adult Life
593 Citations1982Shirley A. Bayer, James Yackel +1 more
These results demonstrate a numerical increase in a neuronal population during adulthood in the mammalian brain in rats 30, 120, 200, and 365 days old.
The Journal of Comparative NeurologyDevelopment of glial cells in the cerebral wall of ferrets: Direct tracing of their transformation from radial glia into astrocytes
548 Citations1989Thomas Voigt
Coronal sections of the cerebral wall from developing ferrets (newborn to adult) were double‐stained with antibodies to vimentin and glial fibrillary acidic protein (GFAP) and around this time they gradually lost their vimentin staining, and in the adult no vimentin‐positive elements were seen except at the ependymal surface.
Developmental Brain ResearchTransition between immature radial glia and mature astrocytes studied with a monoclonal antibody to vimentin
533 Citations1984Sarah K. Pixley, Jean de Vellis
The distribution patterns of RBA1-positive cells led to hypotheses concerning the possible function of vimentin in astrocytes and its regulation during development and wounding.
ScienceClonally Related Cortical Cells Show Several Migration Patterns
507 Citations1988Christopher A. Walsh, C. L. Cepko
This hypothesis that the cortex consists of radial, ontogenetic units of clonally related neurons was tested by studying cell lineage in the rat cortex with a retroviral vector carrying the Escherichia coli beta-galactosidase gene, which can be easily visualized.
The Journal of Comparative NeurologyAstrocyte‐specific protein and neuroglial differentiation. An immunofluorescence study with antibodies to the glial fibrillary acidic protein
494 Citations1974A. Bignami, D. Dahl
In the mature brain and spinal cord the distribution and appearance of neuroglia as observed with immunofluorescence were similar to those described by Weigert ('95) using his method for astrocytic fibers.
NeuronGenetic deletion of a neural cell adhesion molecule variant (N-CAM-180) produces distinct defects in the central nervous system
475 Citations1993Henry Tomasiewicz, Katsuhiko Ono +5 more
Analysis of the mutant in the olfactory bulb suggests that the mutant phenotype involves a defect in cell migration, possibly through specific loss of the polysialylated form of N-CAM-180, which is expressed in the migration pathway.
ScienceDiverse Migratory Pathways tn the Developing Cerebral Cortex
458 Citations1992Nancy O’Rourke, Michael E. Dailey +2 more
Time-lapse confocal microscopy was used to observe directly the dynamic behaviors of migrating cells in living slices of developing cortex, and the majority of cells migrated along a radial pathway, consistent with the view that cortical neurons migrate along radial glial fibers.
Developmental Brain ResearchIdentification of radial glial cells within the developing murine central nervous system: studies based upon a new immunohistochemical marker
424 Citations1988Jean‐Paul Misson, Michael A. Edwards +2 more
The robustness of the antigen recognized by RC2 makes this probe a valuable tool to study the morphological transformations of the bipolar radial glia during their mitotic turnover, and it provides a sensitive stain for the study of the organization and the histogenetic role of the overall radial fiber system.
NeuronN-CAM mutation inhibits tangential neuronal migration and is phenocopied by enzymatic removal of polysialic acid
412 Citations1994Katsuhiko Ono, Henry Tomasiewicz +2 more
The mutation of N-CAM in mice produces a phenotype dominated by an undersized olfactory bulb and accumulation of precursors in the subependymal layer that can be duplicated by injection of an enzyme that specifically destroys the polysialic acid (PSA) moiety associated with N- CAM.
NatureMigration of young neurons in adult avian brain
356 Citations1988Arturo Álvarez-Buylla, Fernando Nottebohm
It is reported here that small elongated cells, born in the ventricular zone adjacent to the lateral ventricle, differentiate into mature neurons 20–40 days later, after migrating over distances of up to 5 mm.
Journal of NeuroscienceGlial-guided granule neuron migration in vitro: a high-resolution time- lapse video microscopic study
346 Citations1987JC Edmondson, ME Hatten
To study neuronal migration, migrating granule neurons in microcultures prepared from early postnatal cerebellum have been analyzed with time- lapse, video-enhanced differential interference contrast microscopy and revealed a saltatory pattern of advance along the glial fiber.
The Journal of Comparative NeurologyEmbryonic (PSA) N‐CAM reveals chains of migrationg neuroblasts between the lateral ventricle and the olfactory bulb of adult mice
333 Citations1995P. Rousselot, Carlos Lois +1 more
PSA‐N‐CAM localization along the migratory pathway to the olfactory bulb suggests that in the adult brain this molecule plays a role in migration of neuronal precursors.
NatureDispersion of neural progenitors within the germinal zones of the forebrain
271 Citations1993Gord Fishell, Carol A. Mason +1 more
This work visualized cell movement within the ventricular zones of the dorsal and basal regions of the E15 murine telencephalon and suggested that this restriction of cell movements establishes a regional pattern of neurogenesis in the developing brain.
Neuroscience LettersNeurogenesis persists in the subependymal layer of the adult mouse brain
266 Citations1993Frank S. Corotto, Jeffery A Henegar +1 more
It is found that new cells form in the subependymal layer and that they migrate subsequently into the olfactory bulbs where they acquire the nuclear morphology of granule cells and express neuron-specific markers.
Brain Research ReviewsDevelopment and decision-making in the mammalian cerebral cortex
243 Citations1988Susan K. McConnell
It is concluded that early commitment events in the cerebral cortex may specify a neuron's laminar position and restrict the range of potential axonal projections that the cell may form, but that local positional cues direct neurons to select (or maintain) only certain of the possible projections.
Trends in NeurosciencesNeuronal-glial interaction during brain development
239 Citations1981Pasko Rakić
DNA labeling with [ 3 H]thymidine indicates that radial glial cells do not divide during the peak of neurogenesis when their elongated fibers serve as guides for migrating neurons and provide the structural basis for compartmentalization of developing neuron tissue.
Journal of NeuroscienceCortical radial glia: identification in tissue culture and evidence for their transformation to astrocytes
218 Citations1990SM Culican, NL Baumrind +2 more
To test the hypothesis that radial glia become astrocytes when their developmental role is complete, the morphological and immunocytochemical development in culture was examined and it was found that they develop several branched processes; in this transitional stage they are labeled by both RC1 and abGFAP.
NeuroscienceExpression of polysialylated neural cell adhesion molecule by proliferating cells in the subependymal layer of the adult rat, in its rostral extension and in the olfactory bulb
213 Citations1994Luca Bonfanti, D.T. Theodosis
The contention that polysialylation is a feature of neurons capable of dynamic change and may contribute to the molecular mechanisms permitting cell proliferation and migration not only during development but also in the adult is supported.
Journal of NeurosciencePostembryonic growth of the optic tectum in goldfish. I. Location of germinal cells and numbers of neurons produced
184 Citations1983PA Raymond, SS Easter
The topological dissimilarity of the patterns of growth of retina and tectum supports the suggestion that retinotectal terminals must continually move and leads to predictions about the directions and magnitudes of these displacements.
The Journal of Comparative NeurologyGolgi studies on the development of granule cells of the rat olfactory bulb with reference to migration in the subependymal layer
179 Citations1987Kiyoshi Kishi
The morphology and the development of the cells in the subependymal layer and of granule cells of the olfactory bulb were examined by Nissl and Golgi staining in postnatal rats to identify bipolar cells and relatively large cells with many cytoplasmic processes considered to belong to the glial cell line.
The Journal of Comparative NeurologyMonoclonal antibody reveals radial glia in adult avian brain
158 Citations1987Arturo Álvarez-Buylla, Daniel R. Buskirk +1 more
It is believed that the presence of radial glia in the adult avian forebrain and their apparent absence in mammals is related to neurogenesis in adulthood, which occurs in birds and much less or not at all in mammals.
Proceedings of the National Academy of SciencesRadial arrangement of clonally related cells in the chicken optic tectum: lineage analysis with a recombinant retrovirus.
151 Citations1988Glenda Gray, Joel C. Glover +2 more
It is reported that descendants of a single precursor form narrow, radially oriented columns that span the thickness of the developing tectum, which suggests that neurons descended from asingle precursor are richly interconnected and functionally related.
Developmental Brain ResearchDelayed postnatal neurogenesis in the cerebral cortex of lizards
129 Citations1988Carlos López‐García, A. Molowny +2 more
The results show that postnatal neurogenesis in the medial cortex of the lizard occurs following a spatio-temporal pattern reminiscent of that found in the fascia dentata of the mammalian hippocampus.
The Journal of Comparative NeurologyDevelopmental relationships between trigeminal ganglia and trigeminal motoneurons in chick embryos. II. Ganglion axon ingrowth guides motoneuron migration
71 Citations1983Sally A. Moody, Marieta Barrow Heaton
It is demonstrated that the presence of V ganglion perikarya alone is not sufficient to guide the appropriate migration of V motoneurons and this migration occurs only after the axons from the V sensoryganglion cells have penetrated the brainstem.
The Journal of Comparative NeurologyMigratory pathways and selective aggregation of the lateral reticular neurons in the rat embryo: A horseradish peroxidase in vitro study, with special reference to migration patterns of the precerebellar nuclei
63 Citations1990Franck Bourrat, Constantino Sotelo
The ontogeny of the LRN and ECN provides a most surprising example, even unique in the central nervous system, of long‐distance, neurophilic migration that conveys neuronal cell bodies contralaterally to the side on which they proliferate.
Anatomy and EmbryologyDo oculomotor neuroblasts migrate across the midline in the fetal rat brain?
63 Citations1977Luis Puelles, Alain Privat
Toluidine blue-stained semithin sections and Cajal-Castro preparations are used to study in rat fetuses whether oculomotor neuroblasts migrate across the midline at a certain period of development and it was discovered that no preexisting structure guides their movement by contact.
Archives of Histology and CytologyMigration of bipolar subependymal cells, precursors of the granule cells of the rat olfactory bulb, with reference to the arrangement of the radial glial fibers.
62 Citations1990Kiyoshi Kishi, Jun Yun PENG +7 more
In rats during their first 3 weeks of life, the bipolar subependymal cells migrate along the anterior lateral and olfactory ventricles into the center of the Olfactory bulb, whereas the radial glial fibers radiating from the ventricular surface are arranged rather perpendicularly to the direction of migration of bipolar cells.
Cellular and Molecular Life SciencesCell lineage and cell migration in the developing cerebral cortex
57 Citations1990Ch. Walsh, C. L. Cepko
A wide distribution in clone size suggests that progenitor cells may be fairly plastic and responsive to environmental signals in the central nervous system.
Anatomy and EmbryologyMode of neuronal migration of the pontine stream in fetal mice
44 Citations1990Katsuhiko Ono, Koki Kawamura
From the arrangement of the immature neurons and their processes, it can be inferred that developing fibers act as guidance substrates for the translocation of embryonic pontine neurons.
Journal of MorphologyUltrastructure of putative migrating cells in the cerebral cortex of <i>Lacerta galloti</i>
44 Citations1986José Manuel García‐Verdugo, Isabel Fariñas +2 more
Cells considered to be migratory in the cerebral cortex of adult lizards are ultrastructurally of two types; cells with spongy chromatin show an increase in cytoplasmic organelles and progressive chromatin condensation as they travel from the ependymal layer to the granular layer.
The Journal of Comparative NeurologyDynamic changes in the density of radial glial fibers of the developing murine cerebral wall: A quantitative immunohistological analysis
34 Citations1992Jean‐François Gadisseux, Ph. Evrard +2 more
The density of radial glial fibers in the developing murine cerebral wall decreases dramatically during the terminal week of gestation, and variations of fiber density quantitatively are characterized.
Current Opinion in NeurobiologyCortical development and topographic maps: patterns of cell dispersion in developing cerebral cortex
17 Citations1994Karl Herrup, Jerry Silver
To determine whether the ventricular pattern presages the adult, investigators examine the process of cell migration.