Pharmacologic treatment of intermittent claudication.
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TL;DR
A statistically significant improvement in both initial and absolute claudication distances as determined by standardized treadmill walking was present in the pentoxifylline-treated patients.
Abstract
Twenty-six patients with severe short-distance claudication underwent a 24-week, randomized, double-blind, parallel-group evaluation of the efficacy of pentoxifylline in the treatment of intermittent claudication. The primary variables analyzed were the initial and absolute claudication distances as determined by standardized treadmill walking. A statistically significant improvement in both parameters was present in the pentoxifylline-treated patients. Nausea was the only drug side effect noted.