Enhancement of in vitro binding and some of the pharmacological properties of diazepam by a novel anthelmintic agent, avermectin B1a
European Journal of PharmacologyPublished 1 June 1979
Michael Williams, George G. Yarbrough
Citations62
SJR quartileQ1
SJR score1.20
SNIP0.98
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TL;DR
A novel macrocyclic lactone disaccharide anthelmintic agent, Avermectin B1a (AVM) has been found to cause a concentration-dependent increase in the in vitro binding of 3H-diazepam to rat and mouse brain membranes.
Abstract
A novel macrocyclic lactone disaccharide anthelmintic agent, Avermectin B1a (AVM) has been found to cause a concentration-dependent increase in the in vitro binding of 3H-diazepam to rat and mouse brain membranes. The increase in binding is manifested as both an increase in the affinity and number of bindings sites for 3H-diazepam. Preliminary in vivo studies demonstrate that AVM can also enhance some of the pharmacological actions of diazepam.
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Agricultural and Biological Sciences
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