The use of percentage change from baseline as an outcome in a controlled trial is statistically inefficient: a simulation study
BMC Medical Research MethodologyPublished 28 June 2001Open access
Andrew J. Vickers
Citations542
SJR quartileQ1
SJR score1.67
SNIP1.73
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TL;DR
Percentage change from baseline should not be used in statistical analysis and trialists wishing to report this statistic should use another method, such as ANCOVA, and convert the results to a percentage change by using mean baseline scores.
Abstract
Percentage change from baseline should not be used in statistical analysis. Trialists wishing to report this statistic should use another method, such as ANCOVA, and convert the results to a percentage change by using mean baseline scores.
Keywords
MathematicsDecision SciencesEconomics, Econometrics and Finance
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