Transgenic Mice Bearing a Human Mutant Thyroid Hormone βl Receptor Manifest Thyroid Function Anomalies, Weight Reduction, and Hyperactivity
Molecular MedicinePublished 1 May 1997Open access
Rosemary Wong, Vyacheslav V. Vasilyev, Yuan-Tsang Ting, David I. Kutler, Mark C. Willingham, Bruce D. Weintraub
Citations54
SJR quartileQ1
SJR score1.75
SNIP1.19
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TL;DR
Transgenic mice harboring mutant PV have phenotypic features consistent with the commonly observed clinical features of RTH and could be used as a model system to better understand the action of mutant TRβl in a physiological context, which could lead to better treatment for this disease.
Abstract
These mice have phenotypic features consistent with the commonly observed clinical features of RTH and could be used as a model system to better understand the action of mutant TR beta 1 in a physiological context, which could lead to better treatment for this disease.
Keywords
Medicine
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