Horizontal gene transfer of the <i>Escherichia coli pap</i> and <i>prs</i> pili operons as a mechanism for the development of tissue‐specific adhesive properties
Molecular MicrobiologyPublished 1 August 1992
B.‐I. Marklund, Jan M. Tennent, Elisa Garcia, Anja M. Hamers, M. Båga, Frederik P. Lindberg
Citations201
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TL;DR
It is proposed that the retention and spread of pap prs DNA among E. coli is the result of selection pressure exerted by mammalian intestinal isoreceptors.
Abstract
Escherichia coli strains bind to Gal alpha 1-4Gal-containing glycolipids via P pili-associated G-adhesins. Three functional classes of adhesins with different binding specificities are encoded by conserved G-alleles. We suggest that the Class I papG-allele of strain J96 is a novel acquisition possibly introduced via horizontal gene transfer into one of the two P pili gene clusters carried by this strain. Closely related strains in the ECOR collection of natural E. coli isolates carry either a Class II or a Class III G-adhesin. Data indicate that genetic exchanges involving either entire pap or prs gene clusters or individual pap/prs genes have occurred. We propose that the retention and spread of pap/prs DNA among E. coli is the result of selection pressure exerted by mammalian intestinal isoreceptors.
Keywords
Biochemistry, Genetics and Molecular BiologyEnvironmental Science
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