Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin
GastroenterologyPublished 1 February 2001Open access
Akihiro Asakawa, Akio Inui, Oshihiro Kaga, H Yuzuriha, Toshiaki Nagata, Naohiko Ueno
Citations1,181
SJR quartileQ1
SJR score7.20
SNIP5.04
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TL;DR
Ghrelin, which is negatively regulated by leptin and IL-1 beta, is secreted by the stomach and increases arcuate NPY expression, which in turn acts through Y(1) receptors to increase food intake and decrease energy expenditure.
Abstract
: Ghrelin, which is negatively regulated by leptin and IL-1 beta, is secreted by the stomach and increases arcuate NPY expression, which in turn acts through Y(1) receptors to increase food intake and decrease energy expenditure. Gastric peptide ghrelin may thus function as part of the orexigenic pathway downstream from leptin and is a potential therapeutic target not only for obesity but also for anorexia and cachexia.
Keywords
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