Intra-hypothalamic injection of thyrotropin-releasing hormone suppresses brown fat thermogenesis in the anaesthetized rat
Brain ResearchPublished 1 January 1989
Shimon Amir, Robin Pollock, Mary Lagiorgia
Citations8
SJR quartileQ2
SJR score0.85
SNIP0.72
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The present results suggest that some of the effects of TRH on body temperature involve an AHy-mediated inhibitory action on BAT thermogenesis.
Abstract
Thyrotropin-releasing hormone (TRH) has diverse effects on body temperature in rodents, but the effector mechanisms that mediate its thermoregulatory actions are not well defined. In the present study, microinjection of 10 ng to 5 micrograms of TRH into the anterior hypothalamus (AHy) dose-dependently suppressed heat production in interscapular brown adipose tissue (BAT) in chloral hydrate-anaesthetized rats tested at a room temperature of 23 +/- 2 degrees C. This effect of TRH was mimicked by the structurally related peptides acid-TRH and luteinizing hormone releasing hormone (LH-RH), and by the TRH analog CG 3509, but not by the TRH fragments pGlu-His and His-Pro. The AHy plays a role in the regulation of BAT thermogenic activity, and the present results suggest that some of the effects of TRH on body temperature involve an AHy-mediated inhibitory action on BAT thermogenesis.
Keywords
MedicineNeuroscience
Elsevier eBooksThe Rat Brain in Stereotaxic Coordinates
52,250 Citations1982Paxinos, George, Watson, Charles
This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
NatureA role for brown adipose tissue in diet-induced thermogenesis
1,610 Citations1979Nancy J. Rothwell, Michael J. Stock
Measurement of energy balance during voluntary over-eating in rats unequivocally establishes the quantitative importance of diet-induced thermogenesis in energy balance and suggests that this tissue may determine metabolic efficiency and resistance to obesity.
ScienceThyrotropin-Releasing Hormone in Specific Nuclei of Rat Brain
378 Citations1974Michael Brownstein, Miklós Palkovits +3 more
The regional distribution of thyrotropin-releasing hormone (TRH) in rat brain was studied and the greatest concentration of TRH was found in the median eminence.
NatureActivation of brown adipose tissue thermogenesis by the ventromedial hypothalamus
326 Citations1981Martin Perkins, Nancy J. Rothwell +2 more
It is found that electrical stimulation of this area produced increased BAT thermogenesis, which suggests that the VMH exerts a dual influence in the regulation of energy balance—an inhibitory effect on energy intake and a stimulatory effect on thermogenesis and energy output.
American Journal of Physiology-Endocrinology and MetabolismSympathoadrenal system and regulation of thermogenesis
230 Citations1984Lewis Landsberg, M. E. Saville +1 more
It appears likely that dietary changes in SNS activity are related, at least in part, to the changes in metabolic rate that occur in association with changes in dietary intake.
Journal of NeuroscienceAutoradiographic localization of thyrotropin-releasing hormone receptors in the rat central nervous system
190 Citations1985Scott Manaker, Andrew Winokur +2 more
Assessment of the distribution of thyrotropin-releasing hormone (TRH) receptors in the rat CNS suggests that TRH receptors may mediate the actions of TRH in theRat CNS.
Life SciencesAntagonism of ethanol narcosis by thyrotropin releasing hormone
171 Citations1974George R. Breese, Jerry M. Cott +3 more
The ability of TRH to reduce the actions of ethanol after intracisternal injection suggests that the mechanism of the ethanol antagonism is central in origin and the antagonism of ethanol by TRH does not appear to be related to an amphetamine-like stimulant action.
American Journal of Physiology-Regulatory, Integrative and Comparative PhysiologyRole of ventromedial hypothalamus on sympathetic efferents of brown adipose tissue
149 Citations1984Akira Niijima, F. Rohner‐Jeanrenaud +1 more
It is suggested that the VMH area plays a role in increasing the activity of the efferent sympathetic nerves of IBAT during an acute cold stimulus and that alone or in relationship with other, as yet undetermined, central nervous system sites, it has a tonic stimulatory effect on the final common pathways that innervate the IBAT via the efferential sympathetic nerves.
NatureTRH: a possible mediator of thermoregulation
115 Citations1974Geoffrey Metcalf
Results from intraventricular injections of amines suggested that the regulation of body temperature in the cat may be mediated by the release of noradrenaline and 5HT within the hypothalamus.
Brain ResearchHypothalamic control of brown adipose tissue in Zucker lean and obese rats. Effect of electrical stimulation of the ventromedial nucleus and other hypothalamic centres
94 Citations1987S. J. Holt, H.V. Wheal +1 more
The results suggest that the efferent sympathetic pathway from the VMN and other hypothalamic regions of BAT is normal in the obese (fa/fa) rat.
Annual Review of PhysiologyNeurotransmitters in Temperature Control
90 Citations1986James M. Lipton, W. G. Clark
While some peptides, such as adrenocorticotropic hormone (ACTH), have well known func tions in the periphery, the central roles of most peptides are much less un derstood.
The Japanese Journal of PhysiologyThermosensitive neurons in the brain.
87 Citations1985Teruo Nakayama
Biochemical and Biophysical Research CommunicationsThermoregulation in rats: Opposing effects of thyrotropin releasing hormone and its metabolite histidyl-proline diketopiperazine
87 Citations1978Chandan Prasad, Takashi Matsui +2 more
Intraventricular administration of histidyl-proline diketopiperazine to rats produces a dose-dependent hypothermia at 4° or 24°, but not at 31°, suggesting opposing actions of thyrotropin releasing hormone
Pharmacology & TherapeuticsBrain and pituitary peptides in thermoregulation
77 Citations1983W. G. Clark, J. M. Lipton
Proceedings of the Fourth International Symposium on Polarization Phenomena in Nuclear ReactionsControl of Brown Fat Thermogenesis by the Sympathetic Nervous System
67 Citations1978Josiane Seydoux, L Girardier
Electrical stimulation was found to mimick the effects of norepinephrine on the adipocytes, i.e., it caused an increase in both NAD(P)H production and oxygen consumption of the tissue and a depolarization of the cytomembrane.
Cellular and Molecular Life SciencesControl of brown fat thermogenesis by the sympathetic nervous system
46 Citations1977Josiane Seydoux, L Girardier
Neuroscience LettersEffects of thyrotropin releasing hormone injections into different loci of rat brain on core temperature
45 Citations1981G. Bosch, Richard Rips
Intracerebral administration of thyrotropin releasing hormone induces moderate hyperthermia in Sprague--Dawley rats and there is no effect in the stria terminalis.
Brain ResearchHyperthermia induced by pre-pontine knife-cut: Evidence for a tonic inhibition of non-shivering thermogenesis in anaesthetized rat
43 Citations1987Masaaki Shibata, Richard H. Benzi +2 more
It is concluded that the hyperthermia observed after the pre-pontine lesion results from an increased sympathetic stimulation of BAT thermogenesis triggered by the release of a tonic inhibitory control on its heat production.
American Journal of Physiology-Endocrinology and MetabolismRole of autonomic nervous system in postprandial thermogenesis in dogs
39 Citations1987P. Diamond, J. LeBlanc
Cellular and Molecular Life SciencesEffects of thyrotrophic-releasing hormone (TRH) on thermoregulation in the rat
31 Citations1980Mao‐Tsun Lin, A. Chandra +2 more
At ambient temperatures (Ta) of both 8 and 22°C, intraventricular administration of TRH (10–80 μg) produced a dose-dependent hypothermia in rats, and at 30°C Ta, TRH increased metabolic heat production and led to hyperthermia.
Brain Research BulletinEffects of thyrotropin releasing hormone on hypothalamic thermosensitive neurons of the rat
23 Citations1981Steven K. Salzman, Alexander L. Beckman
Results parallel the hyperthermic effects of microinjected TRH and lend further support of the hypothesis that TRH acts as a neurotransmitter or neuromodulator in the POA portion of the CNS thermoregulatory network.
European Journal of PharmacologyCentrally administered thyrotropin-releasing hormone in the regulation of regional blood flow to brown adipose tissue in rats
4 Citations1988Yoko Uchida, Teruko Nomoto
Central administration of TRH affects the regional blood flow to IBAT and appears to interfere with neural mechanisms that involve mediation by the alpha 1-adrenoceptors on the vasculature.
Brain ResearchAging blocks the thermoregulatory action of thyrotropin-releasing hormone in anaesthetized rats
3 Citations1988Shimon Amir
The results suggest that aging impairs the central mechanism(s) involved in the thermoregulatory action of TRH.