Prospective Study of Obstructive Sleep Apnea and Incident Coronary Heart Disease and Heart Failure
CirculationPublished 12 July 2010Open access
Daniel J. Gottlieb, Gayane Yenokyan, Anne B. Newman, George O'connor, Naresh M. Punjabi, Stuart F. Quan
Citations1,539
SJR quartileQ1
SJR score8.67
SNIP8.30
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TL;DR
Obstructive sleep apnea is associated with an increased risk of incident heart failure in community-dwelling middle-aged and older men; its association with incident coronary heart disease in this sample is equivocal.
Abstract
BACKGROUND: Clinic-based observational studies in men have reported that obstructive sleep apnea is associated with an increased incidence of coronary heart disease. The objective of this study was to assess the relation of obstructive sleep apnea to incident coronary heart disease and heart failure in a general community sample of adult men and women. METHODS AND RESULTS: A total of 1927 men and 2495 women > or =40 years of age and free of coronary heart disease and heart failure at the time of baseline polysomnography were followed up for a median of 8.7 years in this prospective longitudinal epidemiological study. After adjustment for multiple risk factors, obstructive sleep apnea was a significant predictor of incident coronary heart disease (myocardial infarction, revascularization procedure, or coronary heart disease death) only in men or =30 were 68% more likely to develop coronary heart disease than those with AHI or =30 were 58% more likely to develop heart failure than those with AHI <5. CONCLUSIONS: Obstructive sleep apnea is associated with an increased risk of incident heart failure in community-dwelling middle-aged and older men; its association with incident coronary heart disease in this sample is equivocal.
Keywords
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