Prenatal stress induces a phase advance of circadian corticosterone rhythm in adult rats which is prevented by postnatal stress
Brain ResearchPublished 1 June 1997
Muriel Koehl, Arnaud Barbazanges, Michel Le Moal, Stefania Maccari
Citations92
SJR quartileQ2
SJR score0.85
SNIP0.72
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TL;DR
The results demonstrate that prenatal stress induces a phase advance in the evening increase of corticosterone levels, and that this change is prevented by postnatal stress, and it appears that the circadian system governing the HPA axis is modifiable by a prenatal stress and remains susceptible to compensatory changes during the postnatal period.
Abstract
Prenatal and postnatal stressors can have different long-term neuroendocrine effects including modifications of stress-induced corticosterone secretion. However, very little is known about the possible long-term effects of prenatal or postnatal stress on the rhythmicity of basal corticosterone secretion in adult offspring. Corticosterone levels were thus determined at six different time points over 24 h in adult rats whose mothers had undergone restraint stress manipulations. The results demonstrate that prenatal stress induces a phase advance in the evening increase of corticosterone levels, and that this change is prevented by postnatal stress. It thus appears that the circadian system governing the HPA axis is modifiable by a prenatal stress, and remains susceptible to compensatory changes during the postnatal period.
Keywords
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