Regulation of dopamine release by presynaptic nicotinic receptors in rat striatal slices: Effect of nicotine in a low concentration
Generate an AI Snapshot to get a quick, structured summary of this paper.
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
It is demonstrated for the first time that a low concentration of nicotine is effective in releasing DA by acting on presynaptic nicotinic receptors located on terminals of the nigro-striatal dopaminergic neurons.
Abstract
Rat striatal slices were continuously superfused with 3H-tyrosine to study the effect of a low concentration of nicotine on the spontaneous release of newly synthesized 3H-dopamine (3H-DA). Nicotine (10−6M) stimulated the calcium-dependent spontaneous release of 3H-DA. This effect was prevented by nicotinic blockers such as pempidine (10−5M) and d-tubocurarine (5×10−6M). The stimulatory effect of nicotine and its blockade by pempidine were still observed in the presence of tetrodotoxin (5×10−7M). This demonstrates for the first time that a low concentration of nicotine is effective in releasing DA by acting on presynaptic nicotinic receptors located on terminals of the nigro-striatal dopaminergic neurons.