The importance of short structural motifs in protein structure analysis
Journal of Computer-Aided Molecular DesignPublished 1 August 1993
Ron Unger, Joel L. Sussman
Citations53
SJR quartileQ2
SJR score0.58
SNIP0.73
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TL;DR
A set of structural building blocks that are very common in protein structure are identified and it is suggested that these building blocks can be used as an important link between the primary sequence and the tertiary structure.
Abstract
Proteins tend to use recurrent structural motifs on all levels of organization. In this paper we first survey the topics of recurrent motifs on the local secondary structure level and on the global fold level. Then, we focus on the intermediate level which we call the short structural motifs. We were able to identify a set of structural building blocks that are very common in protein structure. We suggest that these building blocks can be used as an important link between the primary sequence and the tertiary structure. In this framework, we present our latest results on the structural variability of the extended strand motifs. We show that extended strands can be divided into three distinct structural classes, each with its own sequence specificity. Other approaches to the study of short structural motifs are reviewed.
Keywords
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