Expression of a Multidrug Resistance Gene in Blast Crisis of Chronic Myelogenous Leukemia
Cancer CommunicationsPublished 1 January 1989Open access
Robert Pirker, Lori J. Goldstein, H Ludwig, W Linkesch, Christian Lechner, M M Gottesman
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TL;DR
Three of four patients with chronic myelogenous leukemia in blast crisis were found to express the multidrug resistance (MDR1) gene in their blast cells, which may contribute to the poor response to chemotherapy.
Abstract
Three of four patients with chronic myelogenous leukemia in blast crisis were found to express the multidrug resistance (MDR1) gene in their blast cells. Expression of the MDR1 gene may contribute to the poor response of these patients to chemotherapy.
Keywords
ChemistryMedicineBiochemistry, Genetics and Molecular Biology