Increased synthesis and release of dopamine in the striatum of the rat after amantadine treatment
European Journal of PharmacologyPublished 1 December 1970
B. Scatton, A. Chéramy, Marie‐Jo Besson, J. Głowiński
Citations135
SJR quartileQ1
SJR score1.20
SNIP0.98
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TL;DR
Amantadine pretreatment increased both 3 H-DA synthesis and release and the drug effect on striatal dopamine terminals is discussed with respect to its utilization in human Parkinsonism.
Abstract
Synthesis and release of 3H-dopamine (DA) were estimated by incubating slices of rat striatum with 3,5-3H-L-tyrosine and by measuring the 3H-amine accumulation in slices and incubating medium at the end of the incubation. Absolute 3H-DA synthesis was estimated by measuring the 3H-water quantities formed during the conversion of 3,5-3H-L-tyrosine to 3H-dopa. Amantadine pretreatment increased both 3H-DA synthesis and release. This drug effect on striatal dopaminergic terminals is discussed with respect to its utilization in human Parkinsonism.
Keywords
MedicineNeuroscience
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