Enhancement of Experimental Atherosclerosis by ACTH in the Dog.
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TL;DR
One to 3 injections of 40 units of ACTH-gel significantly enhanced the elevated serum cholesterol and phospholipid levels produced by subsequent thiouracil and cholesterol feeding in the dog, and was associated with paralytic strokes in 4 of 10 dogs.
Abstract
One to 3 injections of 40 units of ACTH-gel significantly enhanced the elevated serum cholesterol and phospholipid levels produced by subsequent thiouracil and cholesterol feeding in the dog. This effect was associated with paralytic strokes in 4 of 10 dogs. Autopsy revealed markedly more widespread and more severe atherosclerosis in dogs pretreated with ACTH than in dogs who received only a high thiouracil and cholesterol diet.