Prolonged reduction of salivary immunoglobulin A (sIgA) after a major academic exam
International Journal of PsychophysiologyPublished 1 September 2000
Renate Deinzer, Christian Kleineidam, R Stiller-Winkler, Helga Idel, Doris Bachg
Citations143
SJR quartileQ1
SJR score0.95
SNIP1.07
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Psychological and immunological stress effects may be dissociated, the latter considerably exceeding the stress period and a closer look at the temporal dynamics of stress-induced immune alterations might increase the understanding of psychoimmuno relationships.
Abstract
Psychological and immunological stress effects may be dissociated, the latter considerably exceeding the stress period. A closer look at the temporal dynamics of stress-induced immune alterations might increase our understanding of psychoimmuno relationships.
Keywords
MedicineNeuroscience
New England Journal of MedicinePsychological Stress and Susceptibility to the Common Cold
1,714 Citations1991Sheldon Cohen, D. A. J. Tyrrell +1 more
Psychological stress was associated in a dose-response manner with an increased risk of acute infectious respiratory illness, and this risk was attributable to increased rates of infection rather than to an increased frequency of symptoms after infection.
Proceedings of the National Academy of SciencesChronic stress alters the immune response to influenza virus vaccine in older adults.
795 Citations1996Janice K. Kiecolt‐Glaser, Ronald Glaser +3 more
It is demonstrated that down-regulation of the immune response to influenza virus vaccination is associated with a chronic stressor in the elderly, which could have implications for vulnerability to infection among older adults.
Psychosomatic MedicinePsychosocial Modifiers of Immunocompetence in Medical Students
791 Citations1984Janice K. Kiecolt‐Glaser, W.L. Garner +4 more
Blood was drawn twice from 75 first‐year medical students, with a baseline sample taken one month before their final examinations and a stress sample drawn on the first day of final examinations to address the effects of a naturally occurring stressor on components of the immune response.
Journal of Behavioral MedicineStress, loneliness, and changes in herpesvirus latency
507 Citations1985Ronald Glaser, Janice K. Kiecolt‐Glaser +2 more
Data suggest that stress-related immunosuppression can significantly modulate herpesvirus latency, and high-loneliness subjects had significantly higher EBV antibody titers than low-lonelsiness subjects.
The LancetACADEMIC STRESS, POWER MOTIVATION, AND DECREASE IN SECRETION RATE OF SALIVARY SECRETORY IMMUNOGLOBULIN A
360 Citations1983JohnB. Jemmott, Myrin Borysenko +5 more
The effect of academic stress on immune function, as measured by the rate of secretion of salivary secretory immunoglobulin A (s-IgA), was studied prospectively in 64 first-year dental school students.
Clinical Immunology and ImmunopathologyThe human IgA system: A reassessment
256 Citations1986Jiří Městecký, Michael W. Russell +2 more
It is proposed that in humans monomeric serum IgA may protect endogenous antigens expressed on various cells and tissues by preventing their interaction with humoral and cellular immune mechanisms that may lead to tissue damage.
Psychosomatic MedicinePsychological Stress as a Determinant of Protein Levels and Salivary-Induced Aggregation of Streptococcus gordonii in Human Whole Saliva
221 Citations1996Jos A. Bosch, H.S. Brand +4 more
The results suggest that acute psychological stress exerts its influence on bothSalivary composition and salivary function, and reduced bacterial aggregation may be a contributing factor in the often reported relationship between stress and impaired oral health.
Brain Behavior and ImmunityStress-related activation of Epstein-Barr virus
213 Citations1991Ronald Glaser, Gary R. Pearson +5 more
Evidence for incomplete reactivation of latent EBV, with only selective expression of the latent virus genome is found, as measured by increases in antibody titers.
Journal of Personality and Social PsychologyEvidence that secretory IgA antibody is associated with daily mood.
202 Citations1987Arthur A. Stone, Donald S. Cox +3 more
This study examined the secretory immune system, the body's first line of defense against invading organisms, and its relation to daily fluctuations of mood, and found that antibody response was lower on days with high negative mood relative to days with lower negative mood and conversely, sIgA antibodies response was higher onDays with high positive Mood relative to Days with lower positive mood.
Social Science & MedicineThe relationship between work stress and oral health status
201 Citations1992Wagner Marcenes, Aubrey Sheiham
Dental caries status was significantly associated with age, socio-economic status, sugar consumption, frequency of dental attendance, toothbrushing frequency, type of toothpaste used, years of residence in Belo Horizonte and marital quality, but Socio- economic status did not remain significant associated with dental caries after adjusting for all the variables studied.
International Journal of PsychophysiologyThe relationship between salivary secretory immunoglobulin A and cortisol: neuroendocrine response to awakening and the diurnal cycle
197 Citations1998Frank Hucklebridge, Angela Clow +1 more
Salivary sIgA showed a similar diurnal cycle to cortisol in a study on eight healthy young adults, and the physiological significance of these relationships and possible implications for vulnerability to infection are discussed.
Health PsychologyDaily events are associated with a secretory immune response to an oral antigen in men.
178 Citations1994Arthur A. Stone, John M. Neale +4 more
To examine a hypothesized link between daily stressful events and secretory immunoglobulin A (sIgA) antibody, 96 adults from the community completed daily event questionnaires and gave daily saliva samples for up to 12 weeks and ingested a capsule of a novel protein to challenge their secretory immune systems.
Journal of Human StressThe Effect of an Academic Examination on Salivary Norepinephrine and Immunoglobulin Levels
176 Citations1985David C. McClelland, Grace Ross +1 more
The examination stimulated adrenergic activity, which in the long run depressed immune function for those with a strong power motive who had been most aroused adrenergically by the examination, and for those for whom n power was stronger.
Journal of Personality and Social PsychologyAcademic stress, social support, and secretory immunoglobulin A.
174 Citations1988John B. Jemmott, Kim Magloire
Students who reported more adequate social support at the preexam period had consistently higher S-IgA levels than did their peers reporting less adequate socialSupport, consonant with the social support direct effects hypothesis, which states that social support enhances health outcomes irrespective of whether the individual is exposed to stressful experiences.
New England Journal of MedicineAntibody Response in Serum and Nasopharynx after Naturally Acquired and Vaccine-Induced Infection with Rubella Virus
174 Citations1971Pearay L. Ogra, Donald Kerr-Grant +3 more
Antibody response to rubella virus was studied in serum and nasopharyngeal secretions after natural infection, intranasal inoculation with RA-27/3 rubella vaccine and subcutaneous administration of HPV-77 DK/12 rubella-virus vaccine.
Archives of General PsychiatryPsychological Stress—Induced Modulation of Interleukin 2 Receptor Gene Expression and Interleukin 2 Production in Peripheral Blood Leukocytes
164 Citations1990Ronald Glaser
The data suggest one mechanism whereby the central nervous system modulates the immune response during psychological stress, and provide the first evidence that this interaction may be observed at the level of gene expression.
Infection and ImmunityHuman immune responses to oral microorganisms: patterns of systemic antibody levels to Bacteroides species
160 Citations1986J L Ebersole, Martin A. Taubman +2 more
Evaluated antibody levels suggested that elevated systemic antibody levels to oral Bacteroides spp.
Biological PsychologyEffects of work demands on immunoglobulin A and cortisol in air traffic controllers
138 Citations1996Hans Zeier, Peter Brauchli +1 more
It is suggested that positive emotional engagement is responsible for the observed sIgA increase and that measuring this physiological response may be a valuable tool for differentiating between positive and negative stress effects or between successful and unsuccessful adaptation or coping with situational demands.
Annual Review of MedicineStructure and Function of Mucosal Antibodies
130 Citations1970T. B. Tomasi
The finding of a predominance of IgA-type plasma cells locally in secretory organs, and the observation that antibodies of the IgA type may be produced by local immunization, support the concept of local synthesis of secretory antibodies.
Behavioral MedicineSecretory IgA as a Measure of Resistance to Infectious Disease: Comments on Stone, Cox, Valdimarsdottir, and Neale
113 Citations1989John B. Jemmott, David C. McClelland
It is concluded that there is no empirical or logical reason to prefer the measurement of another aspect of immunity to total S-IgA concentration in whole saliva, and a meta-analysis suggests a statistically significant relation between S- IgA salivary concentrations and the incidence of acute upper respiratory illnesses.
Journal Of Clinical PeriodontologyIncrease of crevicular interleukin 1b under academic stress at experimental gingivitis sites and at sites of perfect oral hygiene
112 Citations1999Renate Deinzer, Piers Forster +4 more
The results indicate that stress might affect periodontal health by increasing local I1-1beta levels especially when oral hygiene is neglected.
European Journal of PersonalitySituational effects in trait assessment: The FPI, NEOFFI, and EPI questionnaires
111 Citations1995Renate Deinzer, Rolf Steyer +5 more
Behavioral MedicineDynamics of Stress-Related Decrease of Salivary Immunoglobulin A (sIgA): Relationship to Symptoms of the Common Cold and Studying Behavior
109 Citations1998Renate Deinzer, Natalija Schüller
No relationship between sIgA and URT symptoms was observed, nor did students who took academic examinations differ from untested controls in symptom rates, but time spent studying explained a significant proportion in sIGA variation.
Journal of Psychosomatic ResearchInfluence of perceived psychological stress and distress on antibody response to low dose rDNA hepatitis B vaccine
109 Citations1993Lea Jabaaij, P.M. Grosheide +4 more
British Journal of Clinical PsychologyStress, arousal, Cortisol and secretory immunoglobulin A in students undergoing assessment
89 Citations1994Philip Evans, Matt Bristow +3 more
Cortisol, salivary immunoglobulin A, stress and arousal reports were measured in students undergoing academic assessment and all measures were higher on the day of assessment than a week before, and were highest of all immediately after assessment.
American Journal of Physiology-Gastrointestinal and Liver PhysiologyIV. How epithelial transport of IgA antibodies relates to host defense
89 Citations1998Michael E. Lamm
The humoral arm of the mucosal immune system is principally composed of locally synthesized polymeric IgA, whose Fc portion is adapted for binding to the polymeric immunoglobulin receptor that is expressed on the basolateral surface of mucosal epithelial cells, including enterocytes.
NeuroImmunoModulationThe Submandibular Gland: A Key Organ in the Neuro-Immuno-Regulatory Network?
81 Citations1996E Sabbadini, István Berczi
The SMG interacts with the mucosal and systemic compartments of the immune system, with the central and peripheral nervous systems, withThe pituitary gland, and with peripheral endocrine organs, which enable the SMG to exert regulatory influences on immune/inflammatory reactions in the gastrointestinal tract, in the lungs, and possibly elsewhere.
Journal of Human StressSecretory IgA as a Measure of Immunocompetence
76 Citations1987Arthur A. Stone, Donald S. Cox +2 more
Three reasons why total s-IgA protein, the measure derived from radial immunodiffusion assays, may not be a reasonable measure of immune system functioning are presented and an alternative method for examining secretory IgA that focuses on s- IgA antibody response to a novel antigen is suggested.
Immunology TodayThe discovery of secretory IgA and the mucosal immune system
73 Citations1992Thomas B. Tomasi
After completing my medical training, I began an affair with research that has not yet ended and, using gel-diffusion techniques with defined antisera, confirmed that human saliva gave a similar pattern to that of gastric fluid.
American Journal of Respiratory and Critical Care MedicinePsychological Stress and Susceptibility to Upper Respiratory Infections
72 Citations1995Sheldon Cohen
The biologic plausibility of a link between psychological states and host resistance is discussed, and there is still little direct evidence for the nature of neuroendocrine, immune, or behavioral pathways through which stress might alter susceptibility.
Journal Of Clinical PeriodontologyIncrease in gingival inflammation under academic stress
66 Citations1998Renate Deinzer, Stefan Rüttermann +2 more
The hypothesis that psychological stress is a significant risk factor for periodontal inflammation is supported and factors mediating this relationship should be examined.
British Journal of Clinical PsychologyThe relationship between secretory immunity, mood and life‐events
58 Citations1993Phil Evans, Matt Bristow +3 more
Aggregated data across the trial period revealed that unstimulated secretion rate of secretory immunoglobulin A from whole saliva correlated strongly and significantly with net desirable event reporting, defined as a subject's tendency to report relatively frequent desirable events and relatively infrequent undesirable events.
PubMedCompetition stress in soccer coaches increases salivary. Immunoglobin A and salivary cortisol concentrations.
52 Citations1996Joachim Kügler, F Reintjes +2 more
Results show that soccer coaches rated themselves as more excited and tense during the match compared to time points before and after the match of their team, which indicates, that acute psychological stress activates non-specific humoral immune functions.
International Journal of Behavioral MedicineSecretory immunoglobulin a and cardiovascular responses to acute psychological challenge
46 Citations1996Douglas Carroll, Christopher Ring +4 more
Cardiovascular activity and secretory immunoglobulin A in saliva were recorded at rest, during a 30-min computer game task, and during subsequent recovery, providing preliminary indication that sIgA is sensitive to acute psychological challenge in the laboratory.
Biochemical Society TransactionsMucosal immunoglobulins and their contribution to defence mechanisms: an overview
44 Citations1997Jiří Městecký, Michael W. Russell
Clinical & Experimental Immunology<i>Porphyromonas gingivalis</i>-specific serum IgG and IgA antibodies originate from immunoglobulin-secreting cells in inflamed gingiva
44 Citations1991Takuya Ogawa, Yumi Kono +5 more
These studies show that AP patients exhibit brisk serum IgG and IgA subclass anti‐fimbriac antibodies, whose origin appear to be the plasma cells present in the localized inflamed tissues.
Behavioral MedicineSalivary IGA is a Weak Stress Marker
43 Citations1989Christian Mouton, Lise Fillion +2 more
The results suggest that assaying immunoglobulin A in saliva to measure stress may not be as useful in psychophysiological research as expected.
International Journal of Behavioral MedicineAre stress-induced immunological changes mediated by mood? A closer look at how both desirable and undesirable daily events influence siga antibody
34 Citations1996Arthur A. Stone, Christine A. Marco +3 more
Regression analyses indicated that negative mood partially mediated the immunological response to both undesirable and desirable events, and evidence for mediation by positive mood beyond that found for negative mood was weak.
Modulation of secretory immunoglobulin A in saliva in relation to an acute episode of stress and arousal
30 Citations1997Matt Bristow, Frank Hucklebridge +2 more
The results support earlier speculation that in the case of sigA the acute effects of a stressor may be transitory elevation of levels, and are discussed in terms of possible rapid neuroendocrine modulation of the secretory process.
Journal of Obstetric, Gynecologic & Neonatal NursingChildbirth Stress An Immunologic Study
27 Citations1991Cathy Lynn Annie, Maureen Groër
Mothers who had very low or undetectable IgA concentrations when they gave birth had increased incidences of postpartum complications, and their infants had more illnesses during the first six weeks post parturition.
PubMedSalivary composition, gender and psychosocial stress.
23 Citations1993Eli Somer, H. Ben‐Aryeh +1 more
Although male patients reported lower state anxiety than female patients did, their hemodynamic and salivary composition measures indicated a higher sympathetic arousal, possibly reflecting Israeli male patient difficulties in adapting their distress.
European Journal Of Oral SciencesSpecific antibodies against <i>Actinobacillus actinomycetemcomitans</i> in serum and saliva of patients with advanced periodontitis
22 Citations1993Anja Nieminen, Kirsti Kari +1 more
It was concluded that among patients with severe adult periodontitis, the less invasive saliva sample has a diagnostic value equal to that of the serum sample concerning specific antibodies against A.a. in saliva.
Scandinavian Journal of PsychologyPersonality, examination stress and serum concentrations of immunoglobulins
19 Citations1987Olav Vassend, Ragnhild Halvorsen
Multiple regression analysis showed that 34% of the variance in IgM levels could be explained by the variables Somatic complaints and Social alienation, and Immunoglobulin levels were not significantly correlated with serum Cortisol or prolactin concentration.
Journal Of Clinical PeriodontologySpecificity and levels of oral and systemic antibodies to <i>Actinobacillus actinomycetemcomitans</i>
14 Citations1993Per‐Erik Engstöm, Anders Larsson +5 more
Elevated levels of gingival crevicular fluid IgA2 antibodies indicated a local production of IgA from periodontal tissues, and several distinct epitopes on the leukotoxin were recognized by both salivary and serum IgA antibodies.
