Randomized, placebo-controlled trial of bupropion for the treatment of methamphetamine dependence
Drug and Alcohol DependencePublished 13 May 2008Open access
Steven Shoptaw, Keith G. Heinzerling, Erin Rotheram‐Fuller, Trevor Steward, Jason Wang, Aimee-Noelle Swanson
Citations146
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TL;DR
Bupropion was no more effective than placebo in reducing MA use in planned analyses, though bupropion did reduce cigarette smoking.
Abstract
Bupropion was no more effective than placebo in reducing MA use in planned analyses, though bupropion did reduce cigarette smoking. Post hoc findings of an effect for bupropion among baseline light, but not heavy, MA users suggests further evaluation of bupropion for light-MA users is warranted.
Keywords
PsychologyMedicineNeuroscience
Using multivariate statistics
77,462 Citations1983Barbara G. Tabachnick, Linda S. Fidell
In this Section: 1. Multivariate Statistics: Why? and 2. A Guide to Statistical Techniques: Using the Book Research Questions and Associated Techniques.
BiometricsLongitudinal Data Analysis for Discrete and Continuous Outcomes
7,834 Citations1986Scott L. Zeger, Kung‐Yee Liang
A class of generalized estimating equations (GEEs) for the regression parameters is proposed, extensions of those used in quasi-likelihood methods which have solutions which are consistent and asymptotically Gaussian even when the time dependence is misspecified as the authors often expect.
Journal of Substance Abuse TreatmentThe fifth edition of the addiction severity index
4,259 Citations1992A. Thomas McLellan, Harvey Kushner +6 more
The clinical and research uses of the ASI over the past 12 years are discussed, emphasizing some special circumstances that affect its administration.
Journal of Educational and Behavioral StatisticsUsing SAS PROC MIXED to Fit Multilevel Models, Hierarchical Models, and Individual Growth Models
2,713 Citations1998J. David Singer
This paper is written as a step-by-step tutorial that shows how to fit the two most common multilevel models: (a) school effects models, designed for data on individuals nested within naturally occurring hierarchies (e.g., students within classes); and (b) individual growth models,designed for exploring longitudinal data (on individuals) over time.
Archives of General PsychiatryNicotine Dependence and Psychiatric Disorders in the United States
1,265 Citations2004Bridget F. Grant, Deborah S. Hasin +3 more
The results of this study highlight the importance of focusing smoking cessation efforts on individuals who are nicotine dependent, Individuals who have psychiatric disorders, and individuals who have comorbid nicotine dependence and other psychiatric disorders.
Progress in NeurobiologyMechanisms of neurotransmitter release by amphetamines: A review
1,209 Citations2005David Sulzer, Mark S. Sonders +2 more
Current issues on the two apparent primary mechanisms--the redistribution of catecholamines from synaptic vesicles to the cytosol, and induction of reverse transport of transmitter through plasma membrane uptake carriers are reviewed.
American Journal of PsychiatryAssociation of Dopamine Transporter Reduction With Psychomotor Impairment in Methamphetamine Abusers
993 Citations2001Nora D. Volkow, Linda Chang +11 more
American Journal of PsychiatryLow Level of Brain Dopamine D<sub>2</sub> Receptors in Methamphetamine Abusers: Association With Metabolism in the Orbitofrontal Cortex
914 Citations2001Nora D. Volkow, Linda Chang +11 more
The association between level of dopamine D2 receptors and metabolism in the orbit ofrontal cortex in methamphetamine abusers suggests that D2 receptor-mediated dysregulation of the orbitofrontal cortex could underlie a common mechanism for loss of control and compulsive drug intake in drug-addicted subjects.
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767 Citations2004Paul M. Thompson, Kiralee M. Hayashi +8 more
MRI-based maps suggest that chronic methamphetamine abuse causes a selective pattern of cerebral deterioration that contributes to impaired memory performance, and brain substrates may help account for the symptoms of MA abuse, providing therapeutic targets for drug-induced brain injury.
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756 Citations2001Nora D. Volkow, Linda Chang +9 more
It is suggested that protracted abstinence may reverse some of methamphetamine-induced alterations in brain DA terminals, and neuropsychological tests did not improve to the same extent as during short abstinence, which suggests that the increase of the DA transporters was not sufficient for complete function recovery.
Cochrane Database of Systematic ReviewsAntidepressants for smoking cessation
688 Citations2003JR Hughes, LF Stead +1 more
Some antidepressants (bupropion and nortriptyline) can aid smoking cessation, but it is not clear whether these effects are specific for individual drugs, or a class effect.
Journal of NeuroscienceAmphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport
687 Citations1995David Sulzer, T J H Chen +4 more
These experiments indicate that amphetamine acts at the vesicular level where it redistributes dopamine to the cytosol, promoting reverse transport, and dopamine release.
American Journal on AddictionsCo‐Morbidity of Smoking in Patients with Psychiatric and Substance Use Disorders
594 Citations2005David Kalman, Sandra B. Morissette +1 more
JAMAMortality following inpatient addictions treatment. Role of tobacco use in a community-based cohort
573 Citations1996R. Douglas Hurt
Patients previously treated for alcoholism and/or other nonnicotine drug dependence had an increased cumulative mortality that was due more to tobacco-related than to alcohol-related causes, and nicotine dependence treatment is imperative in such high-risk patients.
Cochrane Database of Systematic ReviewsAntidepressants for smoking cessation
570 Citations2007John R. Hughes, Lindsay F Stead +1 more
There is insufficient evidence that adding bupropion or nortriptyline to nicotine replacement therapy provides an additional long-term benefit, and the antidepressants buPropion and nortriptYline appear to be equally effective and of similar efficacy to Nicotine replacement therapy.
JAMATreatment of Depression in Patients With Alcohol or Other Drug Dependence
528 Citations2004Edward V. Nunes, Frances R. Levin
Antidepressant medication exerts a modest beneficial effect for patients with combined depressive- and substance-use disorders, and care should be exercised in the diagnosis of depression-either by observing depression to persist during at least a brief period of abstinence or through efforts by clinical history to screen out substance-related depressive symptoms.
Brain ResearchLong-lasting depletions of striatal dopamine and loss of dopamine uptake sites following repeated administration of methamphetamine
528 Citations1980George C. Wagner, George A. Ricaurte +4 more
Repeated administration of high doses of methamphetamine produced long-term decreases in dopamine levels and in the number of DA uptake sites in the rat striatum, which were dose-related and did not appear to be due to the continued presence of drug in striatal tissue.
Brain Research ReviewsMethamphetamine neurotoxicity: necrotic and apoptotic mechanisms and relevance to human abuse and treatment
523 Citations2001Colin Davidson, Andrew J. Gow +2 more
It is suggested that the commonly used experimental one-day methamphetamine dosing regimen better models the acute overdose pathologies seen in humans, whereas chronic models are needed to accurately model human long-term abuse.
The Primary Care Companion For CNS DisordersA Review of the Neuropharmacology of Bupropion, a Dual Norepinephrine and Dopamine Reuptake Inhibitor
485 Citations2004Stephen M. Stahl, James F. Pradko +4 more
The preclinical and clinical data show that bupropion acts via dual inhibition of norepinephrine and dopamine reuptake and is devoid of clinically significant serotonergic effects or direct effects on postsynaptic receptors.
American Journal on AddictionsPsychiatric Symptoms in Methamphetamine Users
472 Citations2004Joan E. Zweben, Judith B. Cohen +6 more
Findings continue to support the value of integrated treatment for co-occurring conditions, especially the importance of training counseling staff to handle psychotic symptoms when needed.
Addictive BehaviorsThe reliability of a timeline method for assessing normal drinker college students' recent drinking history: Utility for alcohol research
466 Citations1986Mark B. Sobell, Linda C. Sobell +3 more
QF categorization provides a relatively insensitive measure of individual differences in drinking behavior as compared to TL-derived data, which can be used to generate a variety of potentially useful dependent variables, whereas the QF method generates a single variable.
Journal of NeuroscienceMethamphetamine neurotoxicity involves vacuolation of endocytic organelles and dopamine-dependent intracellular oxidative stress
446 Citations1994J.F. Cubells, Stephen Rayport +2 more
It is found that MA is a vacuologenic weak base that induces swelling of endocytic compartments; MA also induces blebbing of the plasma membrane, which suggests that MA redistributes DA from the reducing environment within synaptic vesicles to extravesicular oxidizing environments, thus generating oxygen radicals and reactive metabolites within DA neurons that may trigger selective DA terminal loss.
AddictionStructural and metabolic brain changes in the striatum associated with methamphetamine abuse
430 Citations2007Linda Chang, Daniel Alicata +2 more
Brain structural, chemical and metabolic brain changes, particularly those in the basal ganglia, in individuals who used methamphetamine and in children with prenatal methamphetamine exposure are reviewed, demonstrating abnormalities in brain structure and chemistry convincingly.
Drug and Alcohol DependenceDeficits in response inhibition associated with chronic methamphetamine abuse
419 Citations2005John Monterosso, Adam R. Aron +3 more
MA abuse in this study was associated with a specific deficit in inhibiting a pre-potent response, and response inhibition may serve as a marker for investigating MA abuse in basic science and clinical trials.
NeuronAmphetamine and other psychostimulants reduce pH gradients in midbrain dopaminergic neurons and chromaffin granules: A mechanism of action
386 Citations1990David Sulzer, Stephen Rayport
Inhibition of acidification by psychoactive amines contributes to their pharmacology and may provide a principal molecular mechanism of action of amphetamine.
PsychopharmacologyThe effect of bupropion on nicotine craving and withdrawal
261 Citations2000Saul Shiffman, Joseph A. Johnston +7 more
Bupropion significantly reduced abstinence-associated increases in rated depression, difficulty concentrating, and irritability, and attenuated a decrease in positive affect, and suggested that bupropion might have a positive effect on performance measures during the withdrawal period.
Journal of NeuropsychiatryMethamphetamine Dependence Is Associated With Neurocognitive Impairment in the Initial Phases of Abstinence
259 Citations2003Ari D. Kalechstein, Thomas F. Newton +1 more
These findings are the first to demonstrate that methamphetamine dependence is associated with impairments across a range of neurocognitive domains in a sample of users whose abstinence was continuously monitored with the use of urine screening.
Annals of Internal MedicineEfficacy and Safety of Second-Generation Antidepressants in the Treatment of Major Depressive Disorder
258 Citations2005Richard A. Hansen, Gerald Gartlehner +3 more
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231 Citations2007Ahmed Elkashef, Richard A. Rawson +16 more
The data suggest that bupropion, in combination with behavioral group therapy, was effective for increasing the number of weeks of abstinence in participants with low-to-moderate methamphetamine dependence, mainly male patients, regardless of their comorbid condition.
Preventive MedicineTobacco Use as a Distal Predictor of Mortality Among Long-Term Narcotics Addicts
217 Citations1994Yih‐Ing Hser, William J. McCarthy +1 more
Smoking status and disability history were major distal predictors of subsequent death among long-term narcotics addicts, and tobacco-attributable mortality was directly substantiated as a proximal cause of death by only 16% of the death certificates.
American Journal on AddictionsMethamphetamine Abstinence Syndrome: Preliminary Findings
215 Citations2004Thomas F. Newton, Ari D. Kalechstein +3 more
The abstinence syndrome associated with methamphetamine dependence varied considerably in intensity and duration but generally was mild and resolved quickly for most individuals.
Journal of Biological ChemistryAmphetamine-induced Dopamine Efflux
204 Citations2003Habibeh Khoshbouei, Hongwei Wang +3 more
It is demonstrated that DA efflux mediated by DAT is voltage-dependent, electrogenic, and dependent on intracellular Na+ concentration in the recording electrode, and this model hypothesizes that AMPH-inducedDA efflux depends on two correlated transporter processes.
AddictionA population‐based study of cigarette smoking among illicit drug users in the United States
194 Citations2002Kimber Paschall Richter, Harsohena K. Ahluwalia +3 more
Although most recent illicit drug users smoke, some are able to quit and better understanding of concurrent cigarette and illicit drug use may provide impetus for policy change and shed light on underlying mechanisms of addiction.
Journal of Substance AbuseNicotine and caffeine use in cocaine-dependent individuals
177 Citations1993Alan J. Budney, Stephen T. Higgins +2 more
This study is the first to report on prevalence of smoking and caffeine use among cocaine-dependent individuals, and suggests that use of these other substances may influence the onset and pattern of cocaine use.
Archives of General PsychiatryDrug Abuse Warning Network
174 Citations1981Sarah Hinkley
To the Editor.— The article "The Drug Abuse Warning Network (DAWN) Program: Toxicologic Verification of 1,008 Emergency Room 'Mentions' " by Dr J. Thomas Ungerleider and his colleagues that appeared in the January 1980 issue of the Archives (1980;37:106-109) raises many more questions regarding the authors' research methodology and the validity of their findings than it does regarding the accuracy of DAWN reporting.
American Journal of PsychiatryContingency Management for the Treatment of Methamphetamine Use Disorders
169 Citations2006John M. Roll, Nancy M. Petry +9 more
It is suggested that contingency management has promise as a component in treatment strategies for methamphetamine use disorder and should be considered as an adjunct to psychosocial treatment.
Drug and Alcohol DependenceA multicenter trial of bupropion for cocaine dependence in methadone-maintained patients
168 Citations1995Arthur Margolin, Thomas R. Kosten +9 more
The need to target subgroups of cocaine abusers in future pharmacotherapy trials and the possible role of treatment readiness are discussed.
Archives of General PsychiatrySix-Month Trial of Bupropion With Contingency Management for Cocaine Dependence in a Methadone-Maintained Population
165 Citations2006James Poling, Alison Oliveto +6 more
It is suggested that combining CM with buPropion for the treatment of cocaine addiction may significantly improve outcomes relative to bupropion alone.
NeuropsychopharmacologyBupropion Reduces Methamphetamine-Induced Subjective Effects and Cue-Induced Craving
164 Citations2005Thomas F. Newton, John D. Roache +7 more
Bupropion reduced acute methamphetamine-induced subjective effects and reduced cue-induced craving, and these data provide a rationale for the evaluation of bupropion in the treatment of methamphetamine dependence.
Journal of Emergency MedicineFrequency of acute coronary syndrome in patients presenting to the Emergency Department with chest pain after methamphetamine use
156 Citations2003Samuel D. Turnipseed, John R. Richards +3 more
ACS is common in patients hospitalized for chest pain after MAP use, and the frequency of other potentially life-threatening cardiac complications is not negligible, and a normal EKG lowers the likelihood of ACS.
PsychopharmacologyBupropion occupancy of the dopamine transporter is low during clinical treatment
149 Citations2002Jeffrey H. Meyer, Verdell S. Goulding +4 more
Bupropion treatment occupies less than 22% of DAT sites, which raises the question as to whether a DAT occupancy of less than22% is therapeutic or whether there is another mechanism involved during treatment with bupropion.
Journal of Psychoactive DrugsPsychiatric and Substance Dependence Comorbidities, Sexually Transmitted Diseases, and Risk Behaviors Among Methamphetamine-Dependent Gay and Bisexual Men Seeking Outpatient Drug Abuse Treatment
146 Citations2003Steven Shoptaw, James A. Peck +2 more
Findings indicate that gay and bisexual men seeking outpatient treatment for methamphetamine dependence are likely to experience psychiatric comorbidity and to have high rates of infectious disease, including HIV, syphilis and gonorrhea.
PsychopharmacologyThe acute effects of d-amphetamine and methamphetamine on attention and psychomotor performance
144 Citations2006Beata Y. Silber, Rodney J. Croft +2 more
The current series of studies primarily provides evidence of low-level amphetamines-related enhancement of function; however, it also providesevidence of less conservative movement estimation that might contribute to amphetamine-related road fatalities.
NeuropsychopharmacologyAcute effects of bupropion on extracellular dopamine concentrations in rat striatum and nucleus accumbens studied by in vivo microdialysis
132 Citations1989George G. Nomikos
Increases in DA transmission contribute to the behavioral effects of bupropion and are consistent with a role for DA in the antidepressant effects of this drug, suggesting that the relationship between neurotransmitter release and behavior may be complex.
PubMedMethamphetamine - Effects on Human Performance and Behavior.
131 Citations2002Barry K. Logan
It is concluded that the use of methamphetamine in anything other than low-dose, therapeutic administration with medical oversight raises the likelihood of some impairment of performance in complex psychomotor tasks such as driving.
Brain ResearchRecovery from methamphetamine induced long-term nigrostriatal dopaminergic deficits without substantia nigra cell loss
128 Citations2000Dennis C. Harvey, Goran Laćan +2 more
The magnitude and extent of the dopaminergic deficits, and the subsequent recovery were not suggestive of extensive axonal degeneration followed by regeneration, and this apparent reversibility of the METH-induced neuroadaptations may be related primarily to long-term decreases in expression of VMD-related proteins that recover over time.
Pharmacology Biochemistry and BehaviorCocaine and methamphetamine produce different patterns of subjective and cardiovascular effects
123 Citations2005Thomas F. Newton, Richard De La Garza +2 more
Results reveal differences in the onset, pattern, and duration of subjective and cardiovascular responses following cocaine or methamphetamine administration in stimulant addicted patients, and it is predicted that these differences may impact drug use and relapse patterns, and may have implications in medications development for these addictive disorders.
PsychopharmacologyMethamphetamine self-administration by humans
115 Citations2001Carl L. Hart, Amie S. Ward +3 more
These data demonstrate that oral methamphetamine is a positive reinforcer in humans, and both active methamphetamine doses caused significant reductions in daily total caloric intake, relative to the respective placebo conditions.
AddictionApproaches to the development of medications for the treatment of methamphetamine dependence
114 Citations2007Frank J. Vocci, Nathan M. Appel
The evidence supports the rationale that pharmacotherapies to decrease methamphetamine use, or reduce craving during abstinence may be developed from altering the pharmacokinetics and pharmacodynamics of methamphetamine or its effects on appetitive systems in the brain.
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103 Citations2003Ari D. Kalechstein
Journal of Pharmacology and Experimental TherapeuticsMethylphenidate Alters Vesicular Monoamine Transport and Prevents Methamphetamine-Induced Dopaminergic Deficits
102 Citations2003Verónica Sandoval, Evan L. Riddle +2 more
Results reveal that methylphenidate post-treatment both prevents the persistent dopamine deficits and reverses the acute decreases in vesicular dopamine uptake and VMAT-2 ligand binding caused by methamphetamine treatment.
Journal of Affective DisordersDopamine transporter availability in medication free and in bupropion treated depression: A 99mTc-TRODAT-1 SPECT study
97 Citations2005Miklós Árgyelán, Zoltán Szabó +5 more
The lack of correlation between the efficacy of therapy and occupancy of DAT may raise the question as to whether other mechanisms are involved in the effect of bupropion, and in good agreement with other PET studies.
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95 Citations2004Greene Shepherd, Larissa I. Velez +1 more
After a bupropion overdose, patients frequently display agitation, tachycardia, hallucinations and seizures, which commonly occur within 6 h of the ingestion, however, seizures may occur beyond this time frame, particularly if persistent tachy Cardia, agitation, or hallucinations are noted.
Journal of Pharmacology and Experimental TherapeuticsInteraction Between Hyperthermia and Oxygen Radical Formation in the 5-Hydroxytryptaminergic Response to a Single Methamphetamine Administration
85 Citations1997Annette E. Fleckenstein, Diana G. Wilkins +2 more
Prevention of METH-induced hyperthermia attenuated both the increase in dihydroxybenzoic acid formation and the decrease in TPH activity observed 1 h after METH administration, which suggest that both reactive oxygen species andhyperthermia contribute to the acute decrease inTPH activity.
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Results revealed bupropion rapidly, reversibly, and dose-dependently increased vesicular DA uptake; an effect also associated with VMAT-2 protein redistribution, which demonstrated similarities and differences in the mechanism by which MPD and bupropions affect striatal dopaminergic nerve terminals.
PubMedMethamphetamine-associated acute myocardial infarction and cardiogenic shock with normal coronary arteries: refractory global coronary microvascular spasm.
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A young patient who likely experienced severe, global microvascular coronary spasm unrelieved by intracoronary vasodilator therapy, resulting in acute myocardial infarction is presented.
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70 Citations2006Rachel Gonzales, Patricia Marinelli‐Casey +3 more
A need for targeted education and prevention efforts about hepatitis C among high-risk MA users, including HCV testing coupled with referrals to HCV treatments, is suggested.
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Methamphetamine use causes xerostomia secondary to sympathetic central nervous system activation, rampant caries caused by high-sugar intake in the absence of protective saliva, and bruxism as a result of hyperactivity.
Journal of Pharmacology and Experimental TherapeuticsCocaine-Induced Increases in Vesicular Dopamine Uptake: Role of Dopamine Receptors
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Results suggest that cocaine-induced increases in vesicular DA uptake and DHTBZ binding are mediated by a D(2) receptor-mediated pathway, and indicate that D( 2) receptor activation, per se, is sufficient to increase vesicle DA uptake.
PsycEXTRA DatasetTreatment Effectiveness Score as an Outcome Measure in Clinical Trials
59 Citations1997Walter Ling, Steven Shoptaw +4 more
This chapter reviews the objective indices of treatment response that have traditionally been used and suggests three composite methods for evaluating these data: the Treatment Effectiveness Score (TES), the Joint Probability score (JP), and the Clinical Stabilization Score (CSS).
American Journal of PsychiatryContingency Management for the Treatment of Methamphetamine Use Disorders
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The failure to find an effect for buPropion relative to placebo, when combined with standard cognitive behavioral therapy, dampens enthusiasm for future development of bupropion as a cocaine pharmacotherapy.
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51 Citations1990Terry E. Robinson, Jay Yew +2 more
M methamphetamine-pretreated rats were able to increase their concentration of extracellular DA to the same extent as controls in response to a (+)-amphetamine challenge, and it is suggested that this adaptive response is probably responsible for the absence of obvious behavioral deficits in animals exposed to neurotoxic doses of methamphetamine.
PubMedAcute coronary syndrome and crystal methamphetamine use: a case series.
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A series of eight patients who developed unstable angina or acute myocardial infarction in association with smoking crystal methamphetamine are described, and the findings resemble those with cocaine-associated acute coronary syndromes.
Journal of Addictive DiseasesHIV-Associated Medical, Behavioral, and Psychiatric Characteristics of Treatment-Seeking, Methamphetamine-Dependent Men Who Have Sex with Men
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Findings demonstrate the powerful connection between methamphetamine dependence and HIV infection, and strongly suggest a need for development of interventions that function as both substance abuse treatment and HIV prevention for this population of men.
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This review article is intended to familiarize critical care physicians with the most common street drugs such as amphetamines, ecstasy, cocaine, gamma hydroxybutyrate, opioids, and phencyclidine.
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36 Citations2001Karen E. Sabol, J. Todd Roach +3 more
