Effect of central serotonin depletion on adrenocortical responses to neural stimuli
Experimental NeurologyPublished 1 September 1984
Shaul Feldman, Eldad Melamed, Nissim Conforti, Joseph Weidenfeld
Citations27
SJR quartileQ1
SJR score1.50
SNIP1.05
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TL;DR
The study of rats with 5,7-dihydroxytryptamine or vehicle injected into the raphe nuclei suggested that the depletion of brain serotonin has a differential effect on the transmission of neural impulses which activate the adrenal cortex.
Abstract
In view of the possible role of serotonin in adrenocortical regulation, basal plasma corticosterone concentrations and the response to ether stress, photic, acoustic, or sciatic nerve stimulation, were studied in rats with 5,7-dihydroxytryptamine or vehicle injected into the raphe nuclei. The neurotoxin inhibited the response to photic stimulation without affecting the other modalities. This may suggest that the depletion of brain serotonin has a differential effect on the transmission of neural impulses which activate the adrenal cortex.
Keywords
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