Serotonergic and noradrenergic sensitivity in obsessive-compulsive disorder: behavioral findings
American Journal of PsychiatryPublished 1 August 1988
Eric Hollander, Michael P. Fay, Barry S. Cohen, Raphael Campeas, Jack M. Gorman, Michael R. Liebowitz
Citations140
SJR quartileQ1
SJR score5.27
SNIP3.68
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TL;DR
Six of eight patients with obsessive-compulsive disorder had an exacerbation of symptoms when given m-chlorophenylpiperazine, and six patients given intravenous clonidine experienced marked reduction in obsessions.
Abstract
Six of eight patients with obsessive-compulsive disorder had an exacerbation of symptoms when given m-chlorophenylpiperazine. Fenfluramine and placebo produced mild improvement. Six patients given intravenous clonidine experienced marked reduction in obsessions. Implications for serotonergic and noradrenergic hypotheses of obsessive-compulsive disorder are discussed.
Keywords
PsychologyMedicine
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