Familial breast cancer in males:A case report and review of the literature
CancerPublished 15 December 1986Open access
Frederick K. Kozak, Judith G. Hall, Patricia A. Baird
Citations42
SJR quartileQ1
SJR score2.95
SNIP1.90
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
It appears there are some families in which males as well as females have an increased risk of developing breast cancer.
Abstract
The occurrence of breast cancer in two related males, an uncle and nephew is reported. A review of previously reported cases of male breast cancer occurring in families and the association with other cancers in other family members is included. In previous reports on breast cancer in males, familial or hereditary factors have not generally been recognized as a major contributing factor. Of ten families reported (including our own) where there is sufficient information given, six families (60%) had females with breast cancer. It appears there are some families in which males as well as females have an increased risk of developing breast cancer.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
Annals of Internal MedicineSoft-Tissue Sarcomas, Breast Cancer, and Other Neoplasms
1,483 Citations1969Frederick P. Li, JOSEPH F. FRAUMENI
A new "familial" syndrome of neoplastic diseases in which heredity or oncogenic agents, or both, may have a causal role is suggested.
CancerGenetic study of breast cancer: Identification of a high risk group
209 Citations1974David E. Anderson
A group of women was identified whose risk for breast cancer was 47‐to 51‐fold higher than that experienced by control women, and the disease in these families developed premenopausally, often bilaterally, and was seemingly associated with ovarian function.
CancerFamilial association of breast/ovarian carcinoma
150 Citations1978Henry T. Lynch, Randall E. Harris +4 more
The significant linear decline in estimates of cumulative breast/ovarian cancer risk to females with diminishing genetic relationship to probands and index cases, plus the lack of excessive site‐specific cancer riskto male relatives, supports a sex‐limited genetic etiology.
Genetic EpidemiologyGenetic epidemiology of breast cancer: Segregation analysis of 200 Danish pedigrees
142 Citations1984Wick R. Williams, David E. Anderson +1 more
An investigation of the genetic epidemiology of breast cancer involving complex segregation analysis of 200 breast cancer pedigrees of Danish extraction is presented, finding the observed distribution of Breast cancer is compatible with transmission of an autosomal‐dominant gene with no evidence for residual family resemblance.
CancerGenetic and pathologic findings in a kindred with hereditary sarcoma breast cancer, brain tumors, leukemia, lung, laryngeal, and adrenal cortical carcinoma
139 Citations1978Henry T. Lynch, Gabriel M. Mulcahy +3 more
Morphological findings coupled with the observed pattern and distribution of cancer in the subject kindred suggest that the cancer‐prone genotype interacts with one or more exogenous factors in causing this familial tumor association.
JNCI Journal of the National Cancer InstituteA Genetic Study of Human Breast Cancer<xref ref-type="fn" rid="FN1">1</xref><xref ref-type="fn" rid="FN2">2</xref>
135 Citations1972David E. Anderson
American Journal of Public Health and the Nations HealthSome Observations on the Epidemiology of Breast Cancer Among Males
85 Citations1963David Schottenfeld, Abraham M. Lilienfeld +1 more
A controlled collaborative field study of male patients with breast cancer might provide etiological leads to the understanding of the pathogenesis of breast cancer among women as well as among men.
CancerBreast cancer in families
83 Citations1977David E. Anderson
An analysis of 489 breast cancer pedigrees was conducted to determine the age at diagnosis and bilaterality rate in patients with different familial patterns of the disease compared with 5,100 unselected patients, and to estimate the lifetime probabilities of breast cancer development in daughters of familial patients.
Cancer Treatment ReviewsMale breast cancer: a review
83 Citations1976Frank L. Meyskeus, Douglass C. Tormey +1 more
A re- view o f breast c a n c e r i n males w i t h special a t t e n t i n to h o r m o n a l p a r a m e t e r s has b e e n undertaken.
Diseases of the Colon & RectumThe cancer-family syndrome
61 Citations1979Henry T. Lynch, Patrick M. Lynch
The ascertainment and evaluation of the kindred demonstrates the clinical utility of regarding such criteria (early cancer onset, multiple primary cancers, proximal colonic involvement) as a basis for selecting cases for more thorough family-history evaluation.
The LancetFAMILIAL MALE BREAST CANCER
52 Citations1976RichardB. Everson, JosephF. Fraumeni +5 more
Infiltrating ductal carcinoma of the breast occurred in a total of six men from two families, implicating a defect in oestrogen production or metabolism in the pathogenesis of male breast neoplasms.
CancerFamilial cancer in the general population
41 Citations1977Samuel Albert, M A Child
In the course of collecting samples of human milk for the National Cancer Institute, family histories have been assembled since 1971, and there were significantly more observed than expected cancers in lineages with cancer of breast, ovary, skin, corpus uteri, stomach, rectum, lung and bronchus, or colon.
CancerFamilial breast cancer and its recognition in an oncology clinic
33 Citations1981Henry T. Lynch, Pamela R. Fain +4 more
Significant heterogeneity for cancer risk among relatives of breast cancer probands is indicated, which suggests that the isolation of high risk families can provide a meaningful resource for in‐depth studies in breast cancer genetics.
CancerBreast cancer in brothersCase reports and a review of 30 cases of male breast cancer
33 Citations1975Donald Marger, Nelson Urdaneta +1 more
The courses of 28 other previously unreported male patients with carcinoma of the breast are reviewed, and the possibility of male breast carcinoma being metastatic disease from the prostate is discussed.
CancerFamilial breast cancer in a normal population
24 Citations1974Henry T. Lynch, Hoda A. Guirgis +2 more
Family histories of cancer of all anatomical sites, with particular emphasis upon carcinoma of the breast, were evaluated in more than 4000 consecutive persons independently at medical centers in Omaha and Detroit, with statistical significance found for breast and prostate cancer.
Archives of SurgeryManagement of Familial Breast Cancer
20 Citations1978Henry T. Lynch
The protocol is designed to aid in the assessment of patients who may become candidates for intensified cancer surveillance and/or prophylactic surgery and it is crucial that family history be highly accurate from the standpoint of genealogic relationships and pathologic tumor verification so that management recommendations may reflect sound risk factor assessment.
CancerA study of familial male breast carcinoma and a second report
16 Citations1980Richard Schwartz, Robert Newell +2 more
It is reported on a second instance of familial male breast carcinoma in which the relationship is between father and son, and both patients show a similar histologic type, papillary adenocarcinoma, which is rarely found in male breast cancer.
Plastic & Reconstructive SurgeryGenetic Counseling, Familial Breast Cancer, and the Surgeonʼs Responsibility
5 Citations1980Henry T. Lynch, William A. Albano +1 more
A hypothetical pedigree, based on extensive clinical experience with familial breast cancer, has been constructed to aid the physician in determining which patients have familial cancer tendencies so that he can then integrate this information for employment of strategy in genetic counseling and management.
DMW - Deutsche Medizinische WochenschriftDas Karzinom der männlichen Brustdrüse - unter besonderer Berücksichtigung therapeutischer und prognostischer Gesichtspunkte
4 Citations1971G. Schmitt, J. Scheffler