Effects of LETS glycoprotein on cell motility
CellPublished 1 June 1978
Imran Ali, Richard O. Hynes
Citations275
SJR quartileQ1
SJR score22.61
SNIP7.62
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TL;DR
The effects of LETS protein on migration are consistent with its effects on cell adhesion, morphology and cytoskeleton, and have potential implications for the determination of cellular migration in vivo.
Abstract
Addition of LETS glycoprotein to normal or transformed cells produces increased migration of the cells, as determined by formation of phagokinetic tracks on gold particle-coated coverslips. These tracks arise by a combination of phagocytosis of the gold particles and cellular migration. Increased motility is also evident on plastic in the absence of gold particles. The added LETS protein attaches to the cells in a fibrillar network, and binding is greater to normal than to transformed cells. The effects of LETS protein on migration are consistent with its effects on cell adhesion, morphology and cytoskeleton, and have potential implications for the determination of cellular migration in vivo.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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