Retinal Vessel Diameters and Their Associations with Age and Blood Pressure
Investigative Ophthalmology & Visual SciencePublished 24 October 2003Open access
Tien Yin Wong, Ronald Klein, Barbara E.K. Klein, Stacy M. Meuer, Larry D. Hubbard
Citations317
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SJR score0.11
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TL;DR
The weaker association of retinal arteriolar diameters and BP in older people may reflect greater sclerosis of the retinal arteries preventing a degree of narrowing with higher BP similar to that seen in younger persons.
Abstract
Retinal arteriolar diameters are narrower in older persons and in persons with higher BP, independent of other factors. The weaker association of retinal arteriolar diameters and BP in older people may reflect greater sclerosis of the retinal arterioles, preventing a degree of narrowing with higher BP similar to that seen in younger persons.
Keywords
Medicine
Clinical ChemistryEnzymatic Determination of Total Serum Cholesterol
9,168 Citations1974Charles C. Allain, Lucy S Poon +3 more
An enzymatic method is described for determination of total serum cholesterol by use of a single aqueous reagent and has excellent precision.
Clinical ChemistryCholesterol determination in high-density lipoproteins separated by three different methods.
1,843 Citations1977Maria F. Lopes‐Virella, Pam Stone +2 more
A simplified method for measuring high-density lipoprotein cholesterol in serum after very-low- and low- density lipoproteins have been precipitated from the specimen with sodium phosphotungstate and Mg2+.
OphthalmologyPrevalence of Age-related Maculopathy
1,832 Citations1992Ronald Klein, Ronald Klein +1 more
Signs of age-related maculopathy are common in people 75 years of age or older and may pose a substantial public health problem.
OphthalmologyThe Beaver Dam Eye Study
1,341 Citations1992Ronald Klein, Ronald Klein +2 more
Data suggest that asymptomatic people discovered to have NIDDM during epidemiologic studies may not need immediate ophthalmoscopic examination at the time of their diagnosis because they have a relatively low risk of danger of visual loss due to diabetic retinopathy at that time.
OphthalmologyMethods for evaluation of retinal microvascular abnormalities associated with hypertension/sclerosis in the atherosclerosis risk in communities study11The authors have no proprietary interest in the equipment and techniques described in this article.
1,166 Citations1999Larry D. Hubbard, Rosemary J. Brothers +7 more
Protocols have been developed for nonmydriatic fundus photography and for evaluation of retinal vascular abnormalities in the ARIC Study and several microvascular changes were significantly associated with higher blood pressure, controlling for gender, race, age, and smoking status.
Elsevier eBooksd-Glucose
851 Citations1965Milton W. Slein
This chapter discusses an enzymatic method for the determination of D -glucose with hexokinase and glucose-6-phosphate dehydrogenase, a method based on the optical method developed by O. Warburg and his collaborators.
JAMARetinal Arteriolar Narrowing and Risk of Coronary Heart Disease in Men and Women
777 Citations2002Tien Yin Wong, Ronald Klein +6 more
Retinal arteriolar narrowing is related to risk of CHD in women but not in men, supporting a more prominent microvascular role in the development of CHd in women than in men.
OphthalmologyThe Beaver Dam Eye Study: Visual Acuity
668 Citations1991Ronald Klein, Ronald Klein +2 more
Multivariate analyses showed both sex (women) and age (older) to be significant and independent predictors of poorer visual acuity.
Survey of OphthalmologyRetinal Microvascular Abnormalities and their Relationship with Hypertension, Cardiovascular Disease, and Mortality
614 Citations2001Tien Yin Wong, Ronald Klein +4 more
There is no convincing evidence of an independent or direct association with atherosclerosis, ischemic heart disease, or cardiovascular mortality, but when reliably quantified, retinal microvascular abnormalities may be useful as risk indicators for cerebrovascular diseases.
OphthalmologyPrevalence of Age-related Lens Opacities in a Population
560 Citations1992Barbara E.K. Klein, Ronald Klein +1 more
The Beaver Dam Eye Study confirms that lens opacities are common in adults in the United States and that women were more severely affected than men.
OphthalmologyPathophysiology of Hypertensive Retinopathy
393 Citations1982Mark O.M. Tso, Lee M. Jampol
The effects of systemic hypertension on the posterior segment of the eye are discussed under the headings of hypertensive choroidopathy, hypertensive retinopathy, and hypertensive optic disc edema.
American Journal of EpidemiologyRetinal Arteriolar Diameters and Elevated Blood Pressure: The Atherosclerosis Risk in Communities Study
353 Citations1999A. Richey Sharrett, Larry D. Hubbard +6 more
The patterns of association suggested that these signs reflect both transient and persisting structural effects of elevated blood pressure, in agreement with the scant pathologic literature available.
OphthalmologyRetinal microvascular abnormalities and 10-year cardiovascular mortality
343 Citations2003Tien Yin Wong, Ronald Klein +6 more
Retinopathy is independently associated with cardiovascular mortality, and associations for other retinal abnormalities were only observed in middle-aged persons, which support recent studies that suggest retinal microvascular abnormalities provide independent information regarding cardiovascular risk.
JAMARetinal Arteriolar Narrowing and Risk of Diabetes Mellitus in Middle-aged Persons
315 Citations2002Tien Yin Wong
Retinal arteriolar narrowing is independently associated with risk of diabetes, supporting a microvascular role in the development of clinical diabetes.
Arteriosclerosis Thrombosis and Vascular BiologyAre Retinal Arteriolar Abnormalities Related to Atherosclerosis?
301 Citations2000Ronald Klein, A. Richey Sharrett +5 more
Results suggest that these arteriolar changes are pathologically distinct from atherosclerosis, and including their measurement in population studies may permit evaluation of the independent contribution of arteriolars disease to various ischemic diseases of the heart, brain, and other organs.
OphthalmologyThe prevalence and risk factors of retinal microvascular abnormalities in older persons
300 Citations2003Tien Yin Wong, Ronald Klein +10 more
It is suggested that retinal microvascular abnormalities reflect processes associated with hypertension but distinct from atherosclerosis, and are common in older persons without diabetes and related to hypertension.
Investigative Ophthalmology & Visual ScienceRelationships between Age, Blood Pressure, and Retinal Vessel Diameters in an Older Population
280 Citations2003Harry Leung, Jie Jin Wang +6 more
Retinal arteriolar and venular diameters narrow with increasing age, and these parameters are inversely related to BP, independent of age, gender, and smoking.
British Journal of OphthalmologyRetinal microvascular abnormalities and blood pressure in older people: the Cardiovascular Health Study
273 Citations2002Tien Yin Wong
The data suggest that retinal microvascular changes reflect severity and duration of hypertension, and generalised retinal arteriolar narrowing and possibly arteriovenous nicking are related to previously elevated blood pressure, independent of concurrent blood pressure.
Archives of OphthalmologyEVALUATION OF OPHTHALMOSCOPIC CHANGES OF HYPERTENSION AND ARTERIOLAR SCLEROSIS
262 Citations1953Harold G. Scheie
I shall emphasize certain concepts which are of value in interpreting the ophthalmoscopic signs of these diseases and describe a system of grading these changes which has proved useful to me.
Clinical ChemistryDetermination of glycosylated hemoglobin by affinity chromatography: comparison with colorimetric and ion-exchange methods, and effects of common interferences.
249 Citations1982Dennis Klenk, Greg T. Hermanson +8 more
The affinity method offers a rapid, simple, precise, and accurate alternative to methods currently in use and gives substantial freedom from many commonerences.
Archives of OphthalmologyHypertension and Retinopathy, Arteriolar Narrowing, and Arteriovenous Nicking in a Population
221 Citations1994Ronald Klein
It is suggested that retinopathy and retinal arteriolar narrowing are common in people with hypertension, and further longitudinal study is necessary to evaluate the public health significance of these retinal lesions regarding possibly increased risk of renal and cardiovascular disease.
The LancetUSEFULNESS OF OPHTHALMOSCOPY IN MILD TO MODERATE HYPERTENSION
187 Citations1989Simon B. Dimmitt, Sandy Eames +4 more
Direct ophthalmoscopy was not clinically useful in the assessment of mild to moderate hypertension, whereas urinary microalbumin excretion correlated strongly with clinic blood pressure.
Archives of OphthalmologyRetinopathy in Older Persons Without Diabetes and Its Relationship to Hypertension
183 Citations1998Tony Yu
This study supports the Beaver Dam Eye Study findings that retinal hemorrhages and microaneurysms are relatively frequent lesions in older people without diabetes and are significantly related to the presence and severity of hypertension.
American Journal of OphthalmologyThe relation of systemic hypertension to changes in the retinal vasculature: the beaver dam eye study
169 Citations1998Ronald Klein, Ronald Klein +1 more
The data show a relation of hypertension to an increased incidence of retinopathy and arteriolar narrowing and suggest that pharmacologic control of blood pressure is related to a lower incidence of these anatomic retinal lesions relative to uncontrolled blood pressure.
American Journal of OphthalmologyReliability of retinal photography in the assessment of retinal microvascular characteristics: the atherosclerosis risk in communities study
151 Citations2002David Couper, Ronald Klein +6 more
Retinal microvascular characteristics, especially computer-assisted quantification of generalized retinal arteriolar narrowing, can be ascertained reliably by standardized photographic grading methods, supporting the validity of their associations with cardiovascular disease.
British Journal of OphthalmologyTHE EYE IN GENERAL VASCULAR DISEASE HYPERTENSION AND ARTERIOSCLEROSIS
126 Citations1957Robert Leishman
There is a danger that the faithful recording of clinical signs, such as "copper-wire" arteries, calibre variations, arterio-venous ratios, and the vagaries of the vascular light reflex, may become the self-imposed limit of legitimate clinical thought concerning the retinal vessels.
EyeVessel diameter changes during the cardiac cycle
120 Citations1994Hean C Chen, Vinod Patel +3 more
It was found that the venous diameter decreased in early systole, increasing thereafter to a maximum level in early diastole and then declined towards end diastoles, and it was concluded that for accurate measurement of retinal blood flow, fundus photographs should be taken synchronised with the electrocardiogram.
JAMAPrognostic Importance of Ophthalmoscopic Findings in Essential Hypertension
103 Citations1966Donald J. Breslin
It is concluded that changes in the optic fundi remain the simplest, most practical, and most accurate guide to prognosis in hypertension, with or without complications.
American Journal of OphthalmologyRetinal arteriolar narrowing and risk of coronary heart disease in men and women: The Atherosclerosis Risk in Communities Study. Wong TY, Klein R, Sharrett AR, Duncan BB, Couper DJ, Tielsch JM, Klein BEK, Hubbard LD. JAMA 2002;287:1153–1159.
87 Citations2002Thomas J. Liesegang
PubMedStudy of the usefulness of optic fundi examination of patients with hypertension in a clinical setting.
64 Citations1995Flávio Danni Fuchs, Marcelo Krieger Maestri +6 more
The results of this study demonstrate that optic fundi examination by internists and cardiologists does not give an accurate assessment of the severity of hypertension in most patients, and that the Keith-Wagener classification of retinopathy has a limited applicability.
American Heart JournalRetinal arteriolar findings and coronary heart disease
54 Citations1991Richard F. Gillum
American Journal of OphthalmologyRetinal arteriolar narrowing and risk of diabetes mellitus in middle-aged persons. Wong TY, Klein R, Sharrett AR, Schmidt MI, Pankow JS, Couper DJ, Klein BEK, Hubbard LD, Duncan BB, for the ARIC Investigators. JAMA 2002;287:2528 -2533.
51 Citations2002Hans E. Grossniklaus
PubMedClassification of Retinal Lesions in the Presence of Vascular Hypertension: Report submitted to the American Ophthalmological Society by the committee on Classification of Hypertensive Disease of the Retina.
42 Citations1947Henry P. Wagener, Grady Clay +1 more