Effects of Leptin on Insulin Sensitivity in Normal Rats
EndocrinologyPublished 1 August 1997Open access
W. I. Sivitz
Citations104
SJR quartileQ1
SJR score1.31
SNIP1.01
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Abstract
To determine whether leptin has insulin sensitizing effects in normal rodents, we measured plasma glucose and insulin concentrations in male Sprague-Dawley rats treated with leptin or vehicle by continuous sc infusion for 48 h. In additional experiments, we examined the acute effect of iv leptin upon insulin sensitivity under conditions of clamped glycemia.
Keywords
MedicineNeuroscience