Inducible Apoptosis as a Safety Switch for Adoptive Cell Therapy
New England Journal of MedicinePublished 2 November 2011Open access
Antonio Di Stasi, Siok‐Keen Tey, Gianpietro Dotti, Yuriko Fujita, Alana A. Kennedy‐Nasser, Caridad Martinez
Citations1,451
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TL;DR
The inducible T-cell safety switch based on the fusion of human caspase 9 to a modified human FK-binding protein, allowing conditional dimerization may increase the safety of cellular therapies and expand their clinical applications.
Abstract
The iCasp9 cell-suicide system may increase the safety of cellular therapies and expand their clinical applications. (Funded by the National Heart, Lung, and Blood Institute and the National Cancer Institute; ClinicalTrials.gov number, NCT00710892.).
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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