Binding of oestradiol to blood proteins and aetiology of breast cancer
International Journal of CancerPublished 15 November 1986
John W. Moore, G.M.G. Clark, Susan Hoare, Rosemary R. Millis, J.L. Hayward, Michelle Quinlan
Citations58
SJR quartileQ1
SJR score2.25
SNIP1.76
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TL;DR
A prospective study of 5,000 women has shown that, compared to controls, those who subsequently developed breast cancer had a higher proportion of their blood oestradiol in the non‐protein‐bound and albumin‐bound fractions (the bio‐available fraction) and a lower proportion in the sex‐hormone‐bound fraction.
Abstract
A prospective study of 5,000 women has shown that, compared to controls, those who subsequently developed breast cancer had a higher proportion of their blood oestradiol in the non-protein-bound and albumin-bound fractions (the bio-available fraction) and a lower proportion in the sex-hormone-bound fraction. The increased proportion of bio-available oestradiol was partly due to a lower concentration of sex-hormone-binding globulin. Weight was excluded as a confounding factor.
Keywords
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