Efficacy of Pneumococcal Vaccination in Adults
Archives of Internal MedicinePublished 12 December 1994
Michael J. Fine
Citations371
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TL;DR
Pneumococcal vaccination appears efficacious in reducing bacteremic pneumococcal pneumonia in low-risk adults, but evidence from randomized controlled trials fails to demonstrate vaccine efficacy for pneumitiscal infection-related or other medical outcomes in the heterogeneous group of subjects currently labeled as high risk.
Abstract
Pneumococcal vaccination appears efficacious in reducing bacteremic pneumococcal pneumonia in low-risk adults. However, evidence from randomized controlled trials fails to demonstrate vaccine efficacy for pneumococcal infection-related or other medical outcomes in the heterogeneous group of subjects currently labeled as high risk.
Keywords
Medicine
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The 6- and 12-valent pneumococcal capsular polysaccharide vaccines were carried out in controlled studies among novice gold miners in South Africa and offer great promise for effective control of illnesses caused by pneumococci.
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The incidence of pneumonia was significantly reduced in the vaccinated group but the mortality rate was not modified, and the concluded in favor of the effectiveness of pneumococcal vaccine: etiological fraction 77.1% (51.2%-89.3% confidence limits, 95% risk).
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