Oxidative Stress in Obstructive Sleep Apnea
CHEST JournalPublished 1 May 2005
Motoo Yamauchi, Hiroshi Nakano, Junko Maekawa, Yukinori Okamoto, Yoshinobu Ohnishi, Takahiro Suzuki
Citations379
SJR quartileQ1
SJR score1.83
SNIP1.83
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The severity of OSA is independently associated with oxidative stress, and among various sleep-disordered breathing parameters, ODI is most closely related to oxidative stress.
Abstract
The severity of OSA is independently associated with oxidative stress. Among various sleep-disordered breathing parameters, ODI is most closely related to oxidative stress.
Keywords
MedicineNeuroscience
SLEEPA New Method for Measuring Daytime Sleepiness: The Epworth Sleepiness Scale
17,210 Citations1991Murray W. Johns
The development and use of a new scale, the Epworth sleepiness scale (ESS), is described, which is a simple, self-administered questionnaire which is shown to provide a measurement of the subject's general level of daytime sleepiness.
New England Journal of MedicineThe Occurrence of Sleep-Disordered Breathing among Middle-Aged Adults
10,226 Citations1993Terry Young, Mari Palta +4 more
The prevalence of undiagnosed sleep-disordered breathing is high among men and is much higher than previously suspected among women, and is associated with daytime hypersomnolence.
New England Journal of MedicineOxygen-Derived Free Radicals in Postischemic Tissue Injury
5,441 Citations1985Franklin H. Epstein, Joe M. McCord
It is now clear that oxygen-derived free radicals play an important part in several models of experimentally induced reperfusion injury, and Dysfunction induced by free radicals may be a major component of ischemic diseases of the heart, bowel, liver, kidney, and brain.
New England Journal of MedicineProspective Study of the Association between Sleep-Disordered Breathing and Hypertension
4,975 Citations2000Paul E. Peppard, Terry Young +2 more
A dose-response association between sleep-disordered breathing at base line and the presence of hypertension four years later was found that was independent of known confounding factors and suggest that sleep- disordered breathing is likely to be a risk factor for hypertension and consequent cardiovascular morbidity in the general population.
The FASEB JournalOxidative DNA damage: mechanisms, mutation, and disease
3,194 Citations2003Marcus S. Cooke, Mark D. Evans +2 more
This review critically addresses the extent to which the in vitro significance of oxidative DNA damage has relevance for the pathogenesis of disease, drawing attention to the multiplicity of proteins with repair activities along with a number of poorly considered effects of damage.
Journal of Clinical InvestigationAngiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.
2,447 Citations1996Sanjay Rajagopalan, Stephan Kurz +5 more
Forms of hypertension associated with elevated circulating levels of angiotensin II may have unique vascular effects not shared by other forms of hypertension because they increase vascular smooth muscle .O2- production via NADH/NADPH oxidase activation.
Journal of Clinical InvestigationHypercholesterolemia increases endothelial superoxide anion production.
1,772 Citations1993Y. Ohara, Timothy E. Peterson +1 more
Increased endothelial O2- production in HV may inactivate endothelium-derived nitric oxide and provide a source for other oxygen radicals, contributing to the early atherosclerotic process.
The American Journal of MedicineThe evolution of free radicals and oxidative stress
1,393 Citations2000Joe M. McCord
Redox regulation of gene expression by superoxide and other related oxidants and antioxidants is beginning to unfold as a vital mechanism in health and disease.
The LancetMITOCHONDRIAL DNA MUTATIONS AS AN IMPORTANT CONTRIBUTOR TO AGEING AND DEGENERATIVE DISEASES
1,190 Citations1989AnthonyW. Linnane, Takayuki Ozawa +2 more
It is proposed that the accumulation of mitochondrial mutations and the subsequent cytoplasmic segregation of these mutations during life is an important contributor both to the ageing process and to several human degenerative diseases.
BMJObstructive sleep apnoea syndrome as a risk factor for hypertension: population study
1,025 Citations2000Peretz Lavie
Sleep apnoea syndrome is profoundly associated with hypertension independent of all relevant risk factors, and is a significant predictor of both systolic and diastolic blood pressure after adjustment for age, body mass index, and sex.
CirculationHigh Glucose Increases Nitric Oxide Synthase Expression and Superoxide Anion Generation in Human Aortic Endothelial Cells
767 Citations1997Francesco Cosentino, Keiichi Hishikawa +2 more
The present study demonstrates that prolonged exposure to high glucose increases eNOS gene expression, protein expression, and NO release, however, upregulation of eNos andNO release is associated with a marked concomitant increase of O2- production.
American Journal of Respiratory and Critical Care MedicineIncreased Adhesion Molecules Expression and Production of Reactive Oxygen Species in Leukocytes of Sleep Apnea Patients
742 Citations2002Larissa Dyugovskaya, Peretz Lavie +1 more
It is found that OSA was associated with increased expression of adhesion molecules CD15 and CD11c on monocytes, increased adherence of monocytes in culture to human endothelial cells, increased intracellular ROS production in some monocyte and granulocyte subpopulations, and upregulation of CD15 expression due to hypoxia in vitro in monocytes of control subjects.
Nature GeneticsGenetic analysis of ageing: role of oxidative damage and environmental stresses
649 Citations1996George M. Martin, Steven N. Austad +1 more
The goal here is to seek evidence for common mechanisms among diverse organisms amenable to genetic analysis and oxidative damage is a candidate for such a public mechanism of ageing.
American Journal of Respiratory and Critical Care MedicineEnhanced Release of Superoxide from Polymorphonuclear Neutrophils in Obstructive Sleep Apnea
635 Citations2000Richard Schulz, Siamak Mahmoudi +6 more
OSA is linked with a "priming" of neutrophils for enhanced respiratory burst and the increased superoxide generation, which might have major impact on the development of cardiovascular disorders, is virtually fully reversed by effective CPAP therapy.
StrokeInvestigating the Relationship Between Stroke and Obstructive Sleep Apnea
579 Citations1996Mark Eric Dyken, Virend K. Somers +3 more
Patients with stroke have an increased incidence of obstructive sleep apnea compared with normal sex- and age-matched control subjects, which may have predisposed these patients to stroke.
American Review of Respiratory DiseaseThe Sleep Hypopnea Syndrome
482 Citations1988G A Gould, K. Whyte +5 more
It is confirmed that hypopneas are clinically important and that the "sleep apnea syndrome" may occur in the absence of recurrent apneas.
European Respiratory JournalAn independent association between obstructive sleep apnoea and coronary artery disease
478 Citations1999Yüksel Peker, Holger Kraiczi +4 more
The data suggest a high occurrence of obstructive sleep apnoea in middle-aged and elderly patients with coronary artery disease requiring intensive care, which should be taken into account when considering risk factors for coronary arteries disease.
The Journal of Clinical Endocrinology & MetabolismOxidative Stress Is Associated with Adiposity and Insulin Resistance in Men
413 Citations2003Hideki Urakawa, Akira Katsuki +11 more
The findings showed that the circulating levels of 8-epi-PGF2alpha are related to adiposity and insulin resistance in men, and it is suggested that obesity is an important factor for enhanced oxidative stress and that this oxidative stress triggers the development of insulin Resistance in men.
SLEEPEvidence for Lipid Peroxidation in Obstructive Sleep Apnea
387 Citations2004Lena Lavie, Alona Vishnevsky +1 more
The results support the existence of an increased state of oxidative stress in OSA and its possible involvement in cardiovascular morbidity.
CirculationVitamin C Improves Endothelium-Dependent Vasodilation in Forearm Resistance Vessels of Humans With Hypercholesterolemia
356 Citations1997Henry H. Ting, Farris K. Timimi +4 more
It is concluded that vitamin C improves endothelium-dependent vasodilation in the forearm resistance vessels of patients with hypercholesterolemia, and nitric oxide degradation by oxygen-derived free radicals contributes to abnormal vascular reactivity in hypercholesterololemic humans.
CHEST Journal8-Isoprostane, a Marker of Oxidative Stress, Is Increased in Exhaled Breath Condensate of Patients With Obstructive Sleep Apnea After Night and Is Reduced by Continuous Positive Airway Pressure Therapy
310 Citations2003Giovanna Elisiana Carpagnano, Sergei A. Kharitonov +4 more
It is suggested that systemic and local oxidative stress are increased in OSA patients, and that they are higher after nocturnal apnea and reduced by CPAP therapy.
European Respiratory JournalAbnormal lipid peroxidation in patients with sleep apnoea
245 Citations2000Antònia Barceló, Cristina Miralles +4 more
American Journal of Respiratory and Critical Care MedicinePulmonary Hypertension and Hypoxemia in Obstructive Sleep Apnea Syndrome
236 Citations1994Dimitar Sajkov, Ritchie J. Cowie +3 more
It is concluded that lung disease is not a prerequisite for PH in OSAS and the hypoxemia in PH patients could not be explained by impairment of lung function, greater body mass, or a higher prevalence of smoking.
CardiologyObstructive Sleep Apnea as a Risk Marker in Coronary Artery Disease
222 Citations1999H. Schäfer, Ulrich Koehler +4 more
There is a high prevalence of OSA among patients with angiographically proven CAD and OSA of moderate severity (AHI ≥20) is independently associated with myocardial infarction, and in the care of patients with CAD, particular vigilance for OSA is important.
Sleep MedicineAntioxidant capacity in obstructive sleep apnea patients
176 Citations2003Kostas Christou, Anargyros N. Moulas +2 more
The antioxidant capacity in serum from OSA patients and healthy people was evaluated in order to confirm the hypothesis that there is a relationship between oxidative stress and OSA.
Free Radical ResearchCan oxidative DNA damage be used as a biomarker of cancer risk in humans? Problems, resolutions and preliminary results from nutritional supplementation studies
172 Citations1998Barry Halliwell
Current issues addressed in this article include the problems of artifactual DNA oxidation during isolation and analysis, the relative merits of different analytical methods, the advantages and disadvantages of relying on measurement of 8-hydroxydeoxyguanosine as an index of oxidative DNA damage, and the limited data that are so far available on how diet can affect "steady-state" levels of oxidativeDNA damage in humans.
Journal of the Royal Society of HealthOxygen Free Radicals and Human Diseases
150 Citations1991Okezie I. Aruoma, Harparkash Kaur +1 more
Free RADICALS and other reactive oxygen species are constantly formed in the human body, but they can be toxic when generated in excess and this toxicity is often aggravated by the presence of ions of such transition metals as iron or copper.
PubMedComparison between high-performance liquid chromatography and enzyme-linked immunosorbent assay for the determination of 8-hydroxy-2'-deoxyguanosine in human urine.
117 Citations2002Kayoko Shimoi, Hiroshi Kasai +3 more
Evaluated whether the ELISA system is applicable for comparative human monitoring studies by measuring 8-Hydroxy-2'-deoxyguanosine and high-performance liquid chromatography coupled to an electrochemical detector to determine the absolute value of 8-OH-dG in individual urine samples by ELISA found a good correlation.
Free Radical Biology and MedicineCigarette smoke triggers macrophage adhesion and activation: role of lipid peroxidation products and scavenger receptor
112 Citations2003Paul Kirkham, Gillian Spooner +2 more
Results highlight a potential mechanism by which oxidative stress through the production of reactive carbonyls promotes macrophage accumulation, retention, and activation, independently of other proinflammatory stimuli.
Free Radical ResearchOxidative DNA damage<i>in vivo</i>: Relationship to age, plasma antioxidants, drug metabolism, glutathione-S-transferase activity and urinary creatinine excretion
100 Citations1998Henrik E. Poulsen, Steffen Loft +5 more
PubMedRelationship between obesity and serum markers of oxidative stress and inflammation in Japanese.
97 Citations2003Koji Suzuki, Yoshinori Ito +15 more
Obesity is highly associated with states of oxidative stress and low-grade inflammation in Japanese residents, suggesting that these latter might play an important role in the association between a high BMI and certain cancers as well as coronary heart disease (CHD).
PubMedUrinary 8-oxo-7,8-dihydro-2'-deoxyguanosine values measured by an ELISA correlated well with measurements by high-performance liquid chromatography with electrochemical detection.
91 Citations2002Rie Yoshida, Yasutaka Ogawa +1 more
The results show that the ELISA can be applied to studies comparing relative urinary 8-oxo-dG values among several groups, if the studies do not require determination of the exact concentration of 8-Oxo-DG in urine.
American Journal of Physiology-Endocrinology and MetabolismEndothelium-specific activation of NAD(P)H oxidase in aortas of exogenously hyperinsulinemic rats
89 Citations1999Atsunori Kashiwagi, Kazuya Shinozaki +9 more
Results indicate that production specifically increases in endothelium of aortic tissues in chronic hyperinsulinemic rats through the activation of NAD(P)H oxidase.
Biochemical and Biophysical Research CommunicationsGliclazide protects pancreatic β-cells from damage by hydrogen peroxide
79 Citations2003Kiyoko Kimoto, Kenji Suzuki +11 more
Results suggest that gliclazide reduces oxidative stress of β-cells by H2O2 probably due to its radical scavenging activity, and may be effective in preventing β- cells from the toxic action of reactive oxygen species in diabetes.
Free Radical Biology and MedicineUrinary excretion of three nucleic acid oxidation adducts and isoprostane F2α measured by liquid chromatography-mass spectrometry in smokers, ex-smokers, and nonsmokers
79 Citations2003S. Mitchell Harman, Lynn Liang +7 more
5-OHmU and IsopF(2)alpha are more discriminating of oxidative stress from tobacco smoke than the other two compounds measured and whether characteristic patterns of excretion of these indicators forecast differential disease risk should be explored in future research.
CirculationAttenuation of Nitrate Tolerance and Oxidative Stress by an Angiotensin II Receptor Blocker in Patients With Coronary Spastic Angina
65 Citations2003Nobutaka Hirai, Hiroaki Kawano +10 more
The results suggest that increased oxidative stress induced by activation of angiotensin II may play an important role in the development of nitrate tolerance.
Journal of HypertensionEffects of antihypertensive agents, alpha receptor blockers, beta blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers and calcium channel blockers, on oxidative stress
62 Citations2003Yavuz Baykal, Mahmut İlker Yılmaz +5 more
Investigating the antioxidative system and trace elements in hypertensive patients given different antihypertensive therapy shows that angiotensin-converting enzyme inhibitors and angiotENSin receptor blockers have notable effects on oxidative stress, and are an essential step in managing essential hypertension by the way of improvement of endothelial dysfunction.
American Journal of Physiology-Heart and Circulatory PhysiologyStretch force on vascular smooth muscle cells enhances oxidation of LDL via superoxide production
52 Citations1998Nobutaka Inoue, Seinosuke Kawashima +6 more
The findings suggest that the increased oxidant stress induced by stretch force is one of the potential mechanisms whereby hypertension facilitates atherosclerosis.
International Journal of CardiologyFluvastatin attenuates nitrate tolerance in patients with ischemic heart disease complicating hypercholesterolemia
14 Citations2003Teruo Inoue, Kan Takayanagi +2 more
Fluvastatin attenuated nitrate tolerance in dyslipidemic patients complicated with ischemic heart disease who had been receiving organic nitrates over long period of time, and symptoms of angina were significantly reduced four months after therapy.
