Oseltamivir Resistance during Treatment of Influenza A (H5N1) Infection
New England Journal of MedicinePublished 21 December 2005Open access
M.C.M. de Jong, Tran Tan Thanh, Truong Huu Khanh, Vo Minh Hien, Gavin J. D. Smith, Nguyen Vinh Chau
Citations894
SJR quartileQ1
SJR score19.08
SNIP13.47
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TL;DR
It is suggested that resistance can emerge during the currently recommended regimen of oseltamivir therapy and may be associated with clinical deterioration and that the strategy for the treatment of influenza A (H5N1) virus infection should include additional antiviral agents.
Abstract
Influenza A (H5N1) virus with an amino acid substitution in neuraminidase conferring high-level resistance to oseltamivir was isolated from two of eight Vietnamese patients during oseltamivir treatment. Both patients died of influenza A (H5N1) virus infection, despite early initiation of treatment in one patient. Surviving patients had rapid declines in the viral load to undetectable levels during treatment. These observations suggest that resistance can emerge during the currently recommended regimen of oseltamivir therapy and may be associated with clinical deterioration and that the strategy for the treatment of influenza A (H5N1) virus infection should include additional antiviral agents.
Keywords
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