GATA-3 Is Involved in the Development of Serotonergic Neurons in the Caudal Raphe Nuclei
Journal of NeurosciencePublished 15 June 1999Open access
J. Hikke van Doorninck, Jacqueline van der Wees, Alar Karis, Erika Goedknegt, Michiel Coesmans, Mandy Rutteman
Citations412
SJR quartileQ1
SJR score1.96
SNIP1.30
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TL;DR
It is concluded that GATA-3 plays a major role in the development of the serotonergic neurons of the caudal raphe nuclei, and that it is crucial for their role in locomotion.
Abstract
The GATA-3 transcription factor shows a specific and restricted expression pattern in the developing and adult mouse brain. In the present study we investigated the role of GATA-3 in the caudal raphe system, which is known to operate as a modulator of motor activity. We demonstrate that virtually all neurons in the caudal raphe nuclei that express GATA-3 also produce serotonin. Absence of GATA-3, as analyzed in chimeric -/- mice, affects the cytoarchitecture of serotonergic neurons in the caudal raphe nuclei. As a result the chimeras show a serious defect in their locomotor performance on a rotating rod. In sum, we conclude that GATA-3 plays a major role in the development of the serotonergic neurons of the caudal raphe nuclei, and that it is crucial for their role in locomotion.
Keywords
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