Centromeres of mammalian chromosomes
Trends in GeneticsPublished 1 January 1990
Huntington F. Willard
Citations248
SJR quartileQ1
SJR score3.93
SNIP2.86
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TL;DR
Data from direct functional assays of chromosome segregation are most consistent with a structural and possibly functional role for satellite DNA in the mammalian centromere.
Abstract
The centromere is the major cis-acting genetic locus involved in chromosome segregation in mitosis and meiosis. The mammalian centromere is characterized by large amounts of tandemly repeated satellite DNA and by a number of specific centromere proteins, at least one of which has been shown to interact directly with centromeric satellite DNA sequences. Although direct functional assays of chromosome segregation are still lacking, the data are most consistent with a structural and possibly functional role for satellite DNA in the mammalian centromere.
Keywords
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