Epidemiology of Osteoporosis
Rheumatic Disease Clinics of North AmericaPublished 1 February 2001
Elaine Dennison, Maysam Abdin Mohamed, Cyrus Cooper
Citations234
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SJR score1.12
SNIP1.10
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TL;DR
It is now possible to predict future risk of fracture by measuring BMD with noninvasive techniques, similar to that between blood pressure and stroke, such that fracture risk can be assessed from a definition of osteoporosis using bone mass and past history of fracture.
Abstract
Osteoporotic fractures represent a significant public health burden, which is set to increase in future generations. Lifetime risk is high and lies within the range of 40% to 50% in women and 13% to 22% in men. Life expectancy is increasing worldwide, and it is estimated that the number of individuals aged 65 years and older will increase from the current figure of 323 million to 1555 million by the year 2050. These demographic changes alone can be expected to cause the number of hip fractures occurring worldwide to increase from 1.66 million in 1990 to 6.26 million in 2050. Based on current trends, hip fracture rates might increase in the United Kingdom from 46,000 in 1985 to 117,000 in 2016. The societal cost of these fractures is high; cost-effectiveness analyses showed cost-effectiveness in treating high-risk patients with antiresorptive drugs, particularly if administered as soon as possible after a first fragility fracture.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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28 Citations1993Vera J. Suman, Elizabeth J. Atkinson +3 more
The modified model applies the modified model to baseline ages between 50 and 85 years and any bone mineral density level likely to be observed in the population and the results are displayed in a form more convenient for application in the clinical setting.
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