Adaptive changes of serotonin 5-HT2A receptors in mice lacking the serotonin transporter
Neuroscience LettersPublished 1 March 1999
Agnès Rioux Bilan, Véronique Fabre, Klaus‐Peter Lesch, Rainald Moessner, Dennis L. Murphy, Laurence Lanfumey
Citations107
SJR quartileQ2
SJR score0.77
SNIP0.67
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TL;DR
The serotonin transporter (5-HTT) plays a key-role in the control of serotoninergic neurotransmission and is the target of some antidepressants and possible adaptive changes in brain 5-HT2A receptors were investigated in knock-out mice that do not express the 5- HTT.
Abstract
The serotonin transporter (5-HTT) plays a key-role in the control of serotoninergic neurotransmission and is the target of some antidepressants. Possible adaptive changes in brain 5-HT2A receptors were investigated in knock-out mice that do not express the 5-HTT. Autoradiographic labeling of these receptors by the selective antagonist [3H]MDL 100,907 and saturation experiments with cortical membranes revealed: (1) a new localization of these receptors in the external field of striatum (possibly in striosomes); (2) regional variations in adaptive changes in the density of 5-HT2A receptors in 5-HT(-/-) mutants (-30-40% in the claustrum, cerebral cortex and lateral striatum; no significant change in the striatum core) as compared to wild-type mice.
Keywords
NeuroscienceBiochemistry, Genetics and Molecular BiologyPharmacology, Toxicology and Pharmaceutics
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