Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract
Nature MedicinePublished 7 January 2007
John M. Nicholls, Michael C. W. Chan, Renee W. Y. Chan, Henry K. Wong, Chung Yan Cheung, D L W Kwong
Citations341
SJR quartileQ1
SJR score18.33
SNIP8.71
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TL;DR
It is demonstrated that ex vivo cultures of human nasopharyngeal, adenoid and tonsillar tissues can be infected with H5N1 viruses in spite of an apparent lack of these receptors.
Abstract
Poor human-to-human transmission of influenza A H5N1 virus has been attributed to the paucity of putative sialic acid alpha2-3 virus receptors in the epithelium of the human upper respiratory tract, and thus to the presumed inability of the virus to replicate efficiently at this site. We now demonstrate that ex vivo cultures of human nasopharyngeal, adenoid and tonsillar tissues can be infected with H5N1 viruses in spite of an apparent lack of these receptors.
Keywords
Immunology and MicrobiologyMedicine
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