Building the translational highway: toward new partnerships between academia and the private sector
Nature MedicinePublished 30 April 2003
Ketty Schwartz, Jean‐Thomas Vilquin
Citations25
SJR quartileQ1
SJR score18.33
SNIP8.71
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
At the crossroads of academia and industry, translational research provides the vehicle for the application of medical discoveries and developments and is essential for the continued success in translating basic research findings to the clinic.
Abstract
At the crossroads of academia and industry, translational research provides the vehicle for the application of medical discoveries and developments. A productive and expanded relationship between these two sectors is essential for the continued success in translating basic research findings to the clinic.
Keywords
MedicineEngineering
NatureBone marrow cells regenerate infarcted myocardium
5,167 Citations2001Donald Orlic, Jan Kajstura +10 more
It is indicated that locally delivered bone marrow cells can generate de novo myocardium, ameliorating the outcome of coronary artery disease.
Nature MedicineNeovascularization of ischemic myocardium by human bone-marrow–derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function
2,546 Citations2001Alfred Kocher, Michael Schuster +7 more
It is shown that bone marrow from adult humans contains endothelial precursors with phenotypic and functional characteristics of embryonic hemangioblasts, and that these can be used to directly induce new blood vessel formation in the infarct-bed and proliferation of preexisting vasculature after experimental myocardial infarction.
CirculationHuman Mesenchymal Stem Cells Differentiate to a Cardiomyocyte Phenotype in the Adult Murine Heart
2,241 Citations2002Catalin Toma, Mark F. Pittenger +3 more
The persistence of the engrafted hMSCs and their in situ differentiation in the heart may represent the basis for using these adult stem cells for cellular cardiomyoplasty.
CirculationTransplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI)
2,201 Citations2002Birgit Aßmus, Volker Schächinger +11 more
Proceedings of the National Academy of SciencesMobilized bone marrow cells repair the infarcted heart, improving function and survival
2,090 Citations2001Donald Orlic, Jan Kajstura +8 more
CirculationRepair of Infarcted Myocardium by Autologous Intracoronary Mononuclear Bone Marrow Cell Transplantation in Humans
2,070 Citations2002Bodo E. Strauer, Michael Brehm +6 more
These results demonstrate for the first time that selective intracoronary transplantation of autologous, mononuclear BMCs is safe and seems to be effective under clinical conditions.
Journal of Clinical InvestigationRegeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells
1,966 Citations2001Kathyjo A. Jackson, Susan M. Majka +8 more
The results demonstrate the cardiomyogenic potential of hematopoietic stem cells and suggest a therapeutic strategy that eventually could benefit patients with myocardial infarction.
The LancetAutologous bone-marrow stem-cell transplantation for myocardial regeneration
1,364 Citations2003Christof Stamm, Bernd Westphal +8 more
New England Journal of MedicineChimerism of the Transplanted Heart
1,264 Citations2002Federico Quaini, Konrad Urbanek +7 more
A high level of cardiac chimerism caused by the migration of primitive cells from the recipient to the grafted heart is shown.
Nature MedicineRegenerating functional myocardium: Improved performance after skeletal myoblast transplantation
1,151 Citations1998Doris A. Taylor, B. Zane Atkins +6 more
In rabbits in which myoblasts were incorporated, myocardial performance was improved and the ability to regeneratefunctioning muscle after autologous myoblast transplantation could have a important effect on patients after acuteMyocardial infarction.
Journal of the American College of CardiologyAutologous skeletal myoblast transplantation for severe postinfarction left ventricular dysfunction
1,125 Citations2003Philippe Menasché, Albert Hagège +12 more
These preliminary data suggest the feasibility and safety of autologous skeletal myoblast transplantation in severe ischemic cardiomyopathy, with the caveat of an arrhythmogenic potential, and new-onset contraction of akinetic and nonviable segments suggests a functional efficacy that requires confirmation by randomized studies.
The LancetMyoblast transplantation for heart failure
1,121 Citations2001Philippe Menasché, Albert Hagège +7 more
Success is reported with intramyocardial skeletal muscle transplantation in a patient with severe ischaemic heart failure and there was evidence of contraction and viability in the grafted scar on echocardiography and positron emission tomography 5 months later.
The LancetAngiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation
852 Citations2003Hung‐Fat Tse, Yok‐Lam Kwong +4 more
There was improvement in symptoms, myocardial perfusion, and function at the ischaemic region on MRI after 3 months of follow-up, and future randomised, controlled studies are required to validate this initial encouraging result.
Journal of Clinical InvestigationSkeletal myoblast transplantation for repair of myocardial necrosis.
611 Citations1996Charles E. Murry, Robert W. Wiseman +2 more
Skeletal myoblasts can establish new muscle tissue when grafted into injured hearts, and this muscle can contract when stimulated electrically, because the grafts convert to fatigue-resistant, slow twitch fibers, this new muscle may be suited to a cardiac work load.
ScienceFormation of Nascent Intercalated Disks Between Grafted Fetal Cardiomyocytes and Host Myocardium
598 Citations1994Mark H. Soonpaa, Gou Young Koh +2 more
The results suggest that intracardiac grafting might provide a useful approach for myocardial repair, provided that the grafted cells can contribute to myocardIAL function.
CirculationSurvival, Integration, and Differentiation of Cardiomyocyte Grafts
517 Citations1999Hans Reinecke, Ming Zhang +2 more
Grafted fetal and neonatal cardiomyocytes form new, matureMyocardium with the capacity to couple with injured host myocardium, however, Optimal repair may require reducing the isolation of the graft by the intervening scar tissue.
Journal of the American College of CardiologyAutologous skeletal myoblasts transplanted to ischemia-damaged myocardium in humans
481 Citations2003Francis D. Pagani, H DerSimonian +9 more
Circulation ResearchEvidence for Cardiomyocyte Repopulation by Extracardiac Progenitors in Transplanted Human Hearts
434 Citations2002Michael A. Laflamme, David Myerson +2 more
Adult humans have extracardiac progenitor cells capable of migrating to and repopulating damaged myocardium, but this process occurs at very low levels, and such chimerism involves an injury event.
European Journal of Heart FailureEconomics of Chronic Heart Failure
404 Citations2001Colin Berry, David R. Murdoch +1 more
Economic analyses of chronic heart failure should include both direct and indirect costs of care, and optimization of drug therapy represents the most effective way of reducing costs.
Journal of Molecular and Cellular CardiologySkeletal Muscle Stem Cells Do Not Transdifferentiate Into Cardiomyocytes After Cardiac Grafting
392 Citations2002Hans Reinecke, Veronica Poppa +1 more
It is concluded that satellite cells differentiate into mature skeletal muscle and do not express cardiac-specific genes after grafting into the heart, and transdifferentiation into cardiomyocytes did not occur.
CirculationBone Marrow–Derived Cardiomyocytes Are Present in Adult Human Heart
367 Citations2003Arjun Deb, Shaohua Wang +4 more
Human bone marrow is established for the first time as a source of extracardiac progenitor cells capable of de novo cardiomyocyte formation in transplanted human hearts.
Journal of Thoracic and Cardiovascular SurgeryComparison of the effects of fetal cardiomyocyte and skeletal myoblast transplantation on postinfarction left ventricular function
298 Citations2000Marcio Scorsin, Albert Hagège +7 more
The hypothesis that skeletal myoblasts are as effective as fetal cardiomyocytes for improving postinfarct left ventricular function is supported, based on the possibility for skeletalmyoblasts to be harvested from the patient himself.
The LancetViability and differentiation of autologous skeletal myoblast grafts in ischaemic cardiomyopathy
274 Citations2003Albert Hagège, Claire Carrion +6 more
A 72-year-old man had autologous cultured myoblasts from his vastus lateralis injected to an area of transmural inferior myocardial infarction in non-reperfused scar tissue and showed improvement in symptoms and left-ventricular ejection fraction.
CirculationLong-Term Efficacy of Myoblast Transplantation on Regional Structure and Function After Myocardial Infarction
273 Citations2002Saïd Ghostine, Claire Carrion +8 more
For up to 1 year, Tx of SM limits postinfarction EF deterioration and improves systolic scar function through colonization of fibrosis by skeletal muscle cells with expression of both MHC isoforms, which may confer to the graft the ability to withstand a cardiac-type workload.
Cell TransplantationCell Transplantation for Myocardial Repair: An Experimental Approach
209 Citations1992Daniel Marelli, C. Desrosiers +3 more
Preliminary results could be consistent with the hypothesis that SKM satellite cells can form neo-myocardium within an appropriate environment, after specimens failed to demonstrate the presence of myocyte nuclei.
The Annals of Thoracic SurgeryFactors affecting functional outcome after autologous skeletal myoblast transplantation
180 Citations2001Bruno Pouzet, Jean‐Thomas Vilquin +6 more
Autologous myoblast transplantation is functionally effective over a wide range of postinfarct ejection fractions, including in the sickest hearts provided that they are injected with a sufficiently high number of cells.
PubMedDoes transplantation of cardiomyocytes improve function of infarcted myocardium?
152 Citations1997Marcio Scorsin, Albert Hagège +8 more
Data suggest that transplantation of cardiomyocytes might be an effective means of improving function of infarcted myocardium, as demonstrated by significantly higher 2D ejection fraction and cardiac output after Cellular transplantation.
Journal of Thoracic and Cardiovascular SurgeryCellular therapy reverses myocardial dysfunction
138 Citations2001Charissa Rajnoch, Juan Carlos Chachques +4 more
Satellite cells implanted in a cardiotoxin-induced myocardial lesion survived for a 2-month period and were associated with a significant functional improvement of both local and global contraction.
CirculationIntramyocardial Transplantation of Autologous Myoblasts : Can Tissue Processing Be Optimized?
115 Citations2000Bruno Pouzet, Jean‐Thomas Vilquin +6 more
Cell culture remains mandatory for SM transplantation to be successful but, in a clinical perspective, this process can be made more expeditious by preharvest muscle conditioning with bupivacaine, which greatly enhances the baseline cell yield.
Cardiovascular ResearchLong-term (1 year) functional and histological results of autologous skeletal muscle cells transplantation in rat
71 Citations2003Nawwar Al‐Attar, Claire Carrion +5 more
The functional benefits of autologous skeletal muscle cell transplantation are sustained over time and are associated with either selection, preservation or an increased expression of slow myosin heavy chain isoforms.
CirculationIs Skeletal Myoblast Transplantation Clinically Relevant in the Era of Angiotensin-Converting Enzyme Inhibitors?
56 Citations2001Bruno Pouzet, Saïd Ghostine +7 more
These data provide further support for the clinical relevance of autologous SM cell transplantation in that its cardioprotective effects are additive to those observed with ACE inhibitors.
Journal of the American College of CardiologyBone marrow derived cardiomyocytes are present in adult human heart
33 Citations2003Arjun Deb, Shaohua Wang +3 more
Hearts of female subjects who had undergone sex-mismatched bone marrow transplantation (BMT) were recovered at autopsy and analyzed for the presence of Y chromosome–positive cardiomyocytes, which were not identified in any of the control patients.
Journal of the American College of CardiologySkeletal muscle meets cardiac muscle
29 Citations2003Elina Minami, Hans Reinecke +1 more
Since the early 1990s, cellular cardiomyoplasty (or simply cell transplantation) has been explored as a potential new therapy to alleviate the consequences of myocardial infarction.
ScienceIP Policies and Serving the Public
21 Citations2003Roger N. Beachy
It may be time to ask some hard questions about the university patenting and licensing rush that has emerged after the Bayh-Dole act of 1984.